{"doi":"10.3233/jad-240459","title":"Effect of Genetic Risk on the Relationship Between rs-fMRI Complexity and Tau and Amyloid PET in Alzheimer’s Disease","abstract":"Reduced functional magnetic resonance imaging (fMRI)-complexity in Alzheimer's disease (AD) progression has been demonstrated and found to be associated with tauopathy and cognition. However, association of fMRI-complexity with amyloid and influence of genetic risk (APOEɛ4) remain unknown. Here we investigate the association between fMRI-complexity, tau-PET, and amyloid-PET as well as influence of APOE genotype using multivariate generalized linear models. We show that fMRI-complexity has a strong association with tau but not amyloid deposition and that the presence of an APOEɛ4 allele enhances this effect. Thus fMRI-complexity provides a surrogate marker of impaired brain functionality in AD progression.","journal":"Journal of Alzheimer s Disease","year":2024,"id":458219,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9617,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":522004,"name":"Steven Cen","orcid":"0000-0002-7859-8909","position":1,"is_corresponding":false},{"id":1284537,"name":"M. Danda Vasconcelos Santos","orcid":null,"position":2,"is_corresponding":false},{"id":562030,"name":"Leon Aksman","orcid":"0000-0003-2342-0780","position":3,"is_corresponding":false},{"id":1284104,"name":"Dilmini Wijesinghe","orcid":"0000-0002-2696-6781","position":4,"is_corresponding":false},{"id":364541,"name":"Ru Zhang","orcid":"0000-0001-8744-4525","position":5,"is_corresponding":false},{"id":281096,"name":"Kirsten M. Lynch","orcid":"0000-0003-3976-5783","position":6,"is_corresponding":false},{"id":281099,"name":"John M. Ringman","orcid":"0000-0001-5429-0777","position":7,"is_corresponding":false},{"id":244996,"name":"Danny J.J. Wang","orcid":"0000-0002-0840-7062","position":8,"is_corresponding":false},{"id":243718,"name":"for the Alzheimer’s Disease Neuroimaging Initiative","orcid":null,"position":9,"is_corresponding":false},{"id":288640,"name":"Kay Jann","orcid":"0000-0003-3574-0538","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-19T02:03:46.117860Z","pmid":"39177598","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}