{"doi":"10.3233/jad-231435","title":"Examining a Preclinical Alzheimer’s Cognitive Composite for Telehealth Administration for Reliability Between In-Person and Remote Cognitive Testing with Neuroimaging Biomarkers","abstract":"Background: The preclinical Alzheimer's cognitive composite (PACC) was developed for in-person administration to capture subtle cognitive decline. At the outset of the COVID-19 pandemic, cognitive testing was increasingly performed remotely by telephone or video administration. It is desirable to have a harmonized composite measurement derived from both in-person and remote assessments for identifying cognitive changes and to examine its relationship with common neuroimaging biomarkers. Objective: We defined a telehealth compatible PACC (tPACC) and examined its relationship with neuroimaging biomarkers related to neurodegeneration, brain function and perfusion, white matter integrity, and amyloid-β. Methods: We examined 648 participants' neuroimaging and in-person and remote cognitive testing data from the Wake Forest Alzheimer's Disease Research Center's Clinical Core cohort (observational study) to calculate a modified PACC (PACC5-RAVLT) score and tPACC scores (in-person and remote). We performed Spearman/intraclass correlation coefficient (ICC) analyses for reliability of tPACC scores and linear regression models to evaluate associations between tPACC and neuroimaging. Bland-Altman plots for agreement were constructed across cognitively normal and impaired (mild cognitive impairment and dementia) participants. Results: There was a significant positive relationship between tPACCin - person and PACC5-RAVLT (Overall group: r2 = 0.94, N = 648), and tPACCin - person and tPACCremote (validation subgroup: ICC = 0.82, n = 53). Overall, tPACC showed significant associations with brain thickness/volume, gray matter perfusion, white matter free water, and amyloid-β deposition. Conclusions: There is a good agreement between tPACCand PACC5-RAVLTfor cognitively normal and impaired individuals. The tPACC is associated with common neuroimaging markers of Alzheimer's disease.","journal":"Journal of Alzheimer s Disease","year":2024,"id":450148,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9068,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":295955,"name":"Sarah A. Gaussoin","orcid":"0000-0003-0850-7888","position":1,"is_corresponding":false},{"id":1270708,"name":"L. Latham","orcid":null,"position":2,"is_corresponding":false},{"id":641814,"name":"Melissa M. Rundle","orcid":"0000-0003-4360-216X","position":3,"is_corresponding":false},{"id":226606,"name":"Mark A. Espeland","orcid":"0000-0002-3711-1949","position":4,"is_corresponding":false},{"id":1270339,"name":"Benjamin Williams","orcid":"0000-0003-4766-9337","position":5,"is_corresponding":false},{"id":325846,"name":"Timothy M. Hughes","orcid":"0000-0002-2919-7199","position":6,"is_corresponding":false},{"id":55001,"name":"Suzanne Craft","orcid":"0000-0003-0591-8657","position":7,"is_corresponding":false},{"id":295956,"name":"Bonnie C. Sachs","orcid":"0000-0002-9352-7033","position":8,"is_corresponding":false},{"id":676476,"name":"James R. Bateman","orcid":"0000-0002-3646-9148","position":9,"is_corresponding":false},{"id":584434,"name":"Samuel N. Lockhart","orcid":"0000-0002-0893-5420","position":10,"is_corresponding":false},{"id":961400,"name":"Tuğçe Duran","orcid":"0000-0002-3502-8295","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-19T02:02:25.004119Z","pmid":"38669545","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}