{"doi":"10.3233/jad-230797","title":"Association of Vitamin E and Cognitive Decline in Older Adults with and without the <i>APOE</i> <i>ɛ</i> 4 Allele: A Biracial Population-Based Community Study","abstract":"BACKGROUND: The association of different types of tocopherols (vitamin E) with cognition might vary by the APOEɛ4 allele status. OBJECTIVE: We examined the association of dietary tocopherols with cognitive decline among participants with and without the APOEɛ4 allele over a median of 12 years. METHODS: 2,193 participants from the Chicago Health and Aging Project were included in the analyses. Global cognition was assessed in three-year cycles. We used a 144-item FFQ to assess dietary intakes of tocopherols and hME Sequenom mass-array platform to assess APOE genotype. We used linear mixed effects models to examine the relationship between tocopherol from food sources and global cognitive decline. RESULTS: The mean baseline age was 74.1 (SD = 5.9) years. Among APOEɛ4 carriers, participants in the highest quintile of intakes of dietary vitamin E had a slower cognitive decline of 0.022 SDU (95% CI: 0.000, 0.043) compared to those in the lowest quintile. A higher intake of dietary α-tocopherol from food sources only was associated with slower cognitive decline in APOEɛ4 carriers (p for trend 0.002) but not among the non-carriers (p for trend 0.937). Among APOEɛ4 carriers, those in the highest quintile of intake of α-tocopherol had a 16.4% slower rate of decline of global cognition compared to those in the lowest quintile (β= 0.034, 95% CI: 0.013, 0.054). CONCLUSIONS: Individuals consuming high α-tocopherol from food sources had slower cognitive decline among APOEɛ4 carriers. In older adults, different forms of vitamin E might moderate the relationship of APOEɛ4 with global cognition.","journal":"Journal of Alzheimer s Disease","year":2023,"id":377940,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7924,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":381726,"name":"Carrie J. Finno","orcid":"0000-0001-5924-0234","position":1,"is_corresponding":false},{"id":280506,"name":"Todd Beck","orcid":"0000-0001-8781-2105","position":2,"is_corresponding":false},{"id":38611,"name":"Klodian Dhana","orcid":"0000-0002-6397-7009","position":3,"is_corresponding":false},{"id":628265,"name":"Christy Tangney","orcid":"0000-0002-2431-9687","position":4,"is_corresponding":false},{"id":668400,"name":"Pankaja Desai","orcid":"0000-0002-0904-5905","position":5,"is_corresponding":false},{"id":844214,"name":"Kristin R. Krueger","orcid":"0000-0001-6388-4083","position":6,"is_corresponding":false},{"id":280507,"name":"Denis A. Evans","orcid":"0000-0003-4755-5401","position":7,"is_corresponding":false},{"id":280508,"name":"Kumar B. Rajan","orcid":"0000-0003-1268-4617","position":8,"is_corresponding":false},{"id":628264,"name":"Xiaoran Liu","orcid":"0000-0001-7356-645X","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T01:16:40.346877Z","pmid":"37955092","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}