{"doi":"10.3233/jad-230053","title":"Metabolites and Cognitive Decline in a Puerto Rican Cohort","abstract":"Background: Recent studies have identified plasma metabolites associated with cognitive decline and Alzheimer's disease; however, little research on this topic has been conducted in Latinos, especially Puerto Ricans. Objective: This study aims to add to the growing body of metabolomics research in Latinos to better understand and improve the health of this population. Methods: We assessed the association between plasma metabolites and global cognition over 12 years of follow-up in 736 participants of the Boston Puerto Rican Health Study (BPRHS). Metabolites were measured with untargeted metabolomic profiling (Metabolon, Inc) at baseline. We used covariable adjusted linear mixed models (LMM) with a metabolite * time interaction term to identify metabolites (of 621 measured) associated with ∼12 years cognitive trajectory. Results: We observed strong inverse associations between medium-chain fatty acids, caproic acid, and the dicarboxylic acids, azelaic and sebacic acid, and global cognition. N-formylphenylalanine, a tyrosine pathway metabolite, was associated with improvement in cognitive trajectory. Conclusions: The metabolites identified in this study are generally consistent with prior literature and highlight a role medium chain fatty acid and tyrosine metabolism in cognitive decline.","journal":"Journal of Alzheimer s Disease","year":2024,"id":455613,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9409,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":399439,"name":"Jong‐Soo Lee","orcid":"0000-0001-5119-0711","position":1,"is_corresponding":false},{"id":399438,"name":"Tammy Scott","orcid":"0000-0002-5186-9430","position":2,"is_corresponding":false},{"id":230956,"name":"Shilpa N Bhupathiraju","orcid":"0000-0001-9910-6777","position":3,"is_corresponding":false},{"id":88925,"name":"José M. Ordovás","orcid":"0000-0002-7581-5680","position":4,"is_corresponding":false},{"id":285327,"name":"Rachel S. Kelly","orcid":"0000-0003-3023-1822","position":5,"is_corresponding":false},{"id":341750,"name":"Katherine L. Tucker","orcid":"0000-0001-7640-662X","position":6,"is_corresponding":false},{"id":449517,"name":"Natalia Palacios","orcid":"0000-0002-0643-7735","position":7,"is_corresponding":false},{"id":1279718,"name":"Scott Paul Gordon","orcid":"0000-0002-3377-6548","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T02:03:22.974789Z","pmid":"38578885","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}