{"doi":"10.3233/jad-221159","title":"Impact of Yoga Versus Memory Enhancement Training on Hippocampal Connectivity in Older Women at Risk for Alzheimer’s Disease","abstract":"BACKGROUND: Yoga may be an ideal early intervention for those with modifiable risk factors for Alzheimer's disease (AD) development. OBJECTIVE: To examine the effects of Kundalini yoga (KY) training versus memory enhancement training (MET) on the resting-state connectivity of hippocampal subregions in women with subjective memory decline and cardiovascular risk factors for AD. METHODS: Participants comprised women with subjective memory decline and cardiovascular risk factors who participated in a parent randomized controlled trial (NCT03503669) of 12-weeks of KY versus MET and completed pre- and post-intervention resting-state magnetic resonance imaging scans (yoga: n = 11, age = 61.45±6.58 years; MET: n = 11, age = 64.55±6.41 years). Group differences in parcellated (Cole-anticevic atlas) hippocampal connectivity changes (post- minus pre-intervention) were evaluated by partial least squares analysis, controlling for age. Correlations between hippocampal connectivity and perceived stress and frequency of forgetting (assessed by questionnaires) were also evaluated. RESULTS: A left anterior hippocampal subregion assigned to the default mode network (DMN) in the Cole-anticevic atlas showed greater increases in connectivity with largely ventral visual stream regions with KY than with MET (p < 0.001), which showed associations with lower stress (p < 0.05). Several posterior hippocampal subregions assigned to sensory-based networks in the Cole-anticevic atlas showed greater increases in connectivity with regions largely in the DMN and frontoparietal network with MET than with KY (p < 0.001), which showed associations with lower frequency of forgetting (p < 0.05). CONCLUSION: KY training may better target stress-related hippocampal connectivity, whereas MET may better target hippocampal sensory-integration supporting better memory reliability, in women with subjective memory decline and cardiovascular risk factors.","journal":"Journal of Alzheimer s Disease","year":2023,"id":343011,"datarank":0.48428128021610684,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.07807375005077526,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.07807375005077526,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":11,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9232,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03503669"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":422645,"name":"Prabha Siddarth","orcid":"0000-0001-8746-6353","position":1,"is_corresponding":false},{"id":526706,"name":"Beatrix Krause","orcid":"0000-0001-5495-6348","position":2,"is_corresponding":false},{"id":435687,"name":"Michaela M. Milillo","orcid":"0000-0003-1370-8297","position":3,"is_corresponding":false},{"id":1080492,"name":"Yesenia Aguilar‐Faustino","orcid":null,"position":4,"is_corresponding":false},{"id":423403,"name":"Linda M. Ercoli","orcid":null,"position":5,"is_corresponding":false},{"id":314811,"name":"Katherine L. Narr","orcid":"0000-0002-9396-7936","position":6,"is_corresponding":false},{"id":1080059,"name":"Dharma Singh Khalsa","orcid":"0000-0002-6373-5173","position":7,"is_corresponding":false},{"id":303747,"name":"Helen Lavretsky","orcid":"0000-0001-9990-5085","position":8,"is_corresponding":false},{"id":339220,"name":"Lisa A. Kilpatrick","orcid":"0000-0003-2148-5214","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T01:11:17.288563Z","pmid":"37482992","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}