{"doi":"10.3233/jad-221035","title":"Altered Anterior Insular Metabolic Connectivity in Asymptomatic\n                    <i>MAPT</i>\n                    P301L Carriers","abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:</jats:title>\n                    <jats:p>The insula is the predominant brain region impaired in behavioral variant frontotemporal dementia (bvFTD). However, structural and functional changes in the sub-insula in the asymptomatic stage of bvFTD are unknown.</jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:</jats:title>\n                    <jats:p>\n                      To describe structural and functional changes in insula subregions in asymptomatic carriers of the P301L mutation of the microtubule-associated protein tau (\n                      <jats:italic toggle=\"yes\">MAPT</jats:italic>\n                      ) gene and patients with bvFTD.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:</jats:title>\n                    <jats:p>\n                      Six asymptomatic\n                      <jats:italic toggle=\"yes\">MAPT</jats:italic>\n                      P301L mutation carriers and 12\n                      <jats:italic toggle=\"yes\">MAPT</jats:italic>\n                      negative control subjects of the same pedigree were enrolled, along with 30 patients with a clinical diagnosis of bvFTD and 30 matched controls. All subjects underwent hybrid positron emission tomography/magnetic resonance imaging. Atlas-based parcellation using a fine-grained Brainnetome Atlas was conducted to assess gray matter (GM) volume, metabolism, and metabolic connectivity in the sub-insula (region of interest).\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:</jats:title>\n                    <jats:p>\n                      There was no significant GM atrophy or hypometabolism in insula subregions in asymptomatic\n                      <jats:italic toggle=\"yes\">MAPT</jats:italic>\n                      P301L carriers, although decreased metabolic connectivity between vIa-middle temporal gyrus, vIa-temporal poles, dIa-middle temporal gyrus and dIa-temporal poles; and increased connectivity between vIa-orbitofrontal, vIa-dorsal lateral superior frontal gyrus, and dIa-orbitofrontal and dIa-dorsal lateral superior frontal gyrus were observed. Patients with bvFTD had significant atrophy and hypometabolism in all insula subregions and decreased metabolic connectivity in the whole brain, including vIa/dIa-middle temporal and vIa/dIa-temporal poles. The standardized uptake value ratios of vIa and dIa were negatively associated with Frontal behavior inventory disinhibition scale scores.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusion:</jats:title>\n                    <jats:p>\n                      Metabolic connectivity is altered in vIa and dIa subregions of the sub-insula in\n                      <jats:italic toggle=\"yes\">MAPT</jats:italic>\n                      P301L mutation carriers before the occurrence of atrophy, hypometabolism, and clinical symptoms.\n                    </jats:p>\n                  </jats:sec>","journal":"Journal of Alzheimer’s Disease","year":2023,"id":645411,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1390810,"name":"Deming Jiang","orcid":"0000-0002-8835-5812","position":1,"is_corresponding":false},{"id":1064426,"name":"Li Liu","orcid":"0000-0001-6126-2635","position":2,"is_corresponding":false},{"id":1680548,"name":"Binbin Nie","orcid":null,"position":3,"is_corresponding":false},{"id":357071,"name":"Bo Cui","orcid":"0000-0001-7128-7705","position":4,"is_corresponding":false},{"id":449774,"name":"Yihao Wang","orcid":"0009-0009-4512-6284","position":5,"is_corresponding":false},{"id":1205043,"name":"Pedro Rosa-Neto","orcid":null,"position":6,"is_corresponding":false},{"id":1018655,"name":"Liyong Wu","orcid":"0000-0002-1251-6130","position":7,"is_corresponding":false},{"id":1018654,"name":"Min Chu","orcid":"0000-0001-7572-6162","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Altered Anterior Insular Metabolic Connectivity in Asymptomatic\n                    <i>MAPT</i>\n                    P301L Carriers","abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:</jats:title>\n                    <jats:p>The insula is the predominant brain region impaired in behavioral variant frontotemporal dementia (bvFTD). However, structural and functional changes in the sub-insula in the asymptomatic stage of bvFTD are unknown.</jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:</jats:title>\n                    <jats:p>\n                      To describe structural and functional changes in insula subregions in asymptomatic carriers of the P301L mutation of the microtubule-associated protein tau (\n                      <jats:italic toggle=\"yes\">MAPT</jats:italic>\n                      ) gene and patients with bvFTD.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:</jats:title>\n                    <jats:p>\n                      Six asymptomatic\n                      <jats:italic toggle=\"yes\">MAPT</jats:italic>\n                      P301L mutation carriers and 12\n                      <jats:italic toggle=\"yes\">MAPT</jats:italic>\n                      negative control subjects of the same pedigree were enrolled, along with 30 patients with a clinical diagnosis of bvFTD and 30 matched controls. All subjects underwent hybrid positron emission tomography/magnetic resonance imaging. Atlas-based parcellation using a fine-grained Brainnetome Atlas was conducted to assess gray matter (GM) volume, metabolism, and metabolic connectivity in the sub-insula (region of interest).\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:</jats:title>\n                    <jats:p>\n                      There was no significant GM atrophy or hypometabolism in insula subregions in asymptomatic\n                      <jats:italic toggle=\"yes\">MAPT</jats:italic>\n                      P301L carriers, although decreased metabolic connectivity between vIa-middle temporal gyrus, vIa-temporal poles, dIa-middle temporal gyrus and dIa-temporal poles; and increased connectivity between vIa-orbitofrontal, vIa-dorsal lateral superior frontal gyrus, and dIa-orbitofrontal and dIa-dorsal lateral superior frontal gyrus were observed. Patients with bvFTD had significant atrophy and hypometabolism in all insula subregions and decreased metabolic connectivity in the whole brain, including vIa/dIa-middle temporal and vIa/dIa-temporal poles. The standardized uptake value ratios of vIa and dIa were negatively associated with Frontal behavior inventory disinhibition scale scores.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusion:</jats:title>\n                    <jats:p>\n                      Metabolic connectivity is altered in vIa and dIa subregions of the sub-insula in\n                      <jats:italic toggle=\"yes\">MAPT</jats:italic>\n                      P301L mutation carriers before the occurrence of atrophy, hypometabolism, and clinical symptoms.\n                    </jats:p>\n                  </jats:sec>","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37182866","pmcid":"PMC10357174","openalex_id":"https://openalex.org/W4376271204","authors":[],"funders":[],"total_grants":0,"fwci":0.3164,"citation_percentile":0.56256094,"influential_citations":0,"citation_trend":[{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"bronze","license":"cc-by-nc","oa_locations":[{"url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad221035?id=journal-of-alzheimers-disease%2Fjad221035","host_type":"journal"},{"url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad221035?id=journal-of-alzheimers-disease%2Fjad221035","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/pdf/10.3233/JAD-221035","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/full-xml/10.3233/JAD-221035","host_type":"publisher"},{"url":"https://doi.org/10.3233/jad-221035","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37182866","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10357174","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10357174/pdf/jad-93-jad221035.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10357174","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10357174?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Amyotrophic Lateral Sclerosis Research","Alzheimer's disease research and treatments","Dementia and Cognitive Impairment Research"],"mesh_terms":["Atrophy","Brain","Cerebral Cortex","Humans","Magnetic Resonance Imaging","Temporal Lobe","tau Proteins","Frontotemporal Dementia"],"keywords":["Asymptomatic","Asymptomatic carrier","Neuroscience","Medicine","Biology","Psychology","Internal medicine","Network","microtubule-associated protein tau","Insula","Behavioral Variant Frontotemporal Dementia","18F-fdg-pet"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T05:24:01.177280Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}