{"doi":"10.3233/jad-220366","title":"Blood Pressure and Later-Life Cognition in Hispanic and White Adults (BP-COG): A Pooled Cohort Analysis of ARIC, CARDIA, CHS, FOS, MESA, and NOMAS1","abstract":"BACKGROUND: Ethnic differences in cognitive decline have been reported. Whether they can be explained by differences in systolic blood pressure (SBP) is uncertain. OBJECTIVE: Determine whether cumulative mean SBP levels explain differences in cognitive decline between Hispanic and White individuals. METHODS: Pooled cohort study of individual participant data from six cohorts (1971-2017). The present study reports results on SBP and cognition among Hispanic and White individuals. Outcomes were changes in global cognition (GC) (primary), executive function (EF) (secondary), and memory standardized as t-scores (mean [SD], 50 [10]); a 1-point difference represents a 0.1 SD difference in cognition. Median follow-up was 7.7 (Q1-Q3, 5.2-20.1) years. RESULTS: We included 24,570 participants free of stroke and dementia: 2,475 Hispanic individuals (median age, cumulative mean SBP at first cognitive assessment, 67 years, 132.5 mmHg; 40.8% men) and 22,095 White individuals (60 years,134 mmHg; 47.3% men). Hispanic individuals had slower declines in GC, EF, and memory than White individuals when all six cohorts were examined. Two cohorts recruited Hispanic individuals by design. In a sensitivity analysis, Hispanic individuals in these cohorts had faster decline in GC, similar decline in EF, and slower decline in memory than White individuals. Higher time-varying cumulative mean SBP was associated with faster declines in GC, EF, and memory in all analyses. After adjusting for time-varying cumulative mean SBP, differences in cognitive slopes between Hispanic and White individuals did not change. CONCLUSION: We found no evidence that cumulative mean SBP differences explained differences in cognitive decline between Hispanic and White individuals.","journal":"Journal of Alzheimer s Disease","year":2022,"id":275549,"datarank":0.44645219911917755,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.1010644351700706,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.1010644351700706,"corpus_percentile":57.847915216214126,"corpus_rank":5450,"citation_count":9,"citer_count":6,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5546,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":322305,"name":"Alden L. 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Elkind","orcid":"0000-0003-2562-1156","position":10,"is_corresponding":false},{"id":98925,"name":"Andrew E. Moran","orcid":"0000-0003-3554-0085","position":11,"is_corresponding":false},{"id":305001,"name":"Sarah E. Tom","orcid":"0000-0003-0094-5138","position":12,"is_corresponding":false},{"id":328345,"name":"Rebecca F. Gottesman","orcid":"0000-0002-9504-1256","position":13,"is_corresponding":false},{"id":247231,"name":"Darrell J. Gaskin","orcid":"0000-0002-0822-1583","position":14,"is_corresponding":false},{"id":245382,"name":"Stephen Sidney","orcid":"0009-0008-4556-6426","position":15,"is_corresponding":false},{"id":55010,"name":"Kristine Yaffe","orcid":"0000-0003-0919-3825","position":16,"is_corresponding":false},{"id":247238,"name":"Ralph L. Sacco","orcid":"0000-0003-4629-684X","position":17,"is_corresponding":false},{"id":24969,"name":"Susan R. Heckbert","orcid":"0000-0002-7100-512X","position":18,"is_corresponding":false},{"id":325846,"name":"Timothy M. Hughes","orcid":"0000-0002-2919-7199","position":19,"is_corresponding":false},{"id":245369,"name":"Oscar L. López","orcid":"0000-0002-8546-8256","position":20,"is_corresponding":false},{"id":278983,"name":"Norrina B. Allen","orcid":"0000-0002-6993-4384","position":21,"is_corresponding":false},{"id":231191,"name":"Andrzej T. Gałecki","orcid":"0000-0003-1542-4001","position":22,"is_corresponding":false},{"id":399917,"name":"Deborah A. Levine","orcid":"0000-0002-6864-8001","position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":null,"created_at":"2026-07-19T00:28:21.971703Z","pmid":"35964190","pmcid":"PMC10041434","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}