{"doi":"10.3233/jad-220354","title":"Brain Deep Medullary Veins on 7T MRI in Dutch-Type Hereditary Cerebral Amyloid Angiopathy","abstract":"BACKGROUND: Deep medullary vein (DMV) changes occur in cerebral small vessel diseases (SVD) and in Alzheimer's disease. Cerebral amyloid angiopathy (CAA) is a common SVD that has a high co-morbidity with Alzheimer's disease. So far, DMVs have not been evaluated in CAA. OBJECTIVE: To evaluate DMVs in Dutch-type hereditary CAA (D-CAA) mutation carriers and controls, in relation to MRI markers associated with D-CAA. METHODS: Quantitative DMV parameters length, tortuosity, inhomogeneity, and density were quantified on 7 Tesla 3D susceptibility weighted MRI in pre-symptomatic D-CAA mutation carriers (n = 8), symptomatic D-CAA mutation carriers (n = 8), and controls (n = 25). Hemorrhagic MRI markers (cerebral microbleeds, intracerebral hemorrhages, cortical superficial siderosis, convexity subarachnoid hemorrhage), non-hemorrhagic MRI markers (white matter hyperintensities, enlarged perivascular spaces, lacunar infarcts, cortical microinfarcts), cortical grey matter perfusion, and diffusion tensor imaging parameters were assessed in D-CAA mutation carriers. Univariate general linear analysis was used to determine associations between DMV parameters and MRI markers. RESULTS: Quantitative DMV parameters length, tortuosity, inhomogeneity, and density did not differ between pre-symptomatic D-CAA mutation carriers, symptomatic D-CAA mutation carriers, and controls. No associations were found between DMV parameters and MRI markers associated with D-CAA. CONCLUSION: This study indicates that vascular amyloid-β deposition does not affect DMV parameters. In patients with CAA, DMVs do not seem to play a role in the pathogenesis of MRI markers associated with CAA.","journal":"Journal of Alzheimer s Disease","year":2022,"id":283988,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9586,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":961765,"name":"Anne Heijmans","orcid":null,"position":1,"is_corresponding":false},{"id":526828,"name":"Sanneke van Rooden","orcid":"0000-0002-1468-8403","position":2,"is_corresponding":false},{"id":85621,"name":"Marieke J.H. Wermer","orcid":"0000-0002-6838-9521","position":3,"is_corresponding":false},{"id":473240,"name":"Matthias J.P. van Osch","orcid":"0000-0001-7034-8959","position":4,"is_corresponding":false},{"id":687605,"name":"Hugo J. Kuijf","orcid":"0000-0001-6997-9059","position":5,"is_corresponding":false},{"id":292622,"name":"Susanne J. van Veluw","orcid":"0000-0002-7957-8643","position":6,"is_corresponding":false},{"id":251653,"name":"Steven M. Greenberg","orcid":"0000-0003-1792-8887","position":7,"is_corresponding":false},{"id":245384,"name":"Mark A. van Buchem","orcid":"0000-0003-1881-1998","position":8,"is_corresponding":false},{"id":245370,"name":"Jeroen van der Grond","orcid":"0000-0002-0185-3158","position":9,"is_corresponding":false},{"id":961257,"name":"Marianne A.A. van Walderveen","orcid":"0000-0003-4895-229X","position":10,"is_corresponding":false},{"id":485090,"name":"Thijs W. van Harten","orcid":"0000-0002-3408-9379","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-19T00:29:32.702533Z","pmid":"36120778","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}