{"doi":"10.3233/jad-215719","title":"Serum Levels of α-Klotho Are Correlated with Cerebrospinal Fluid Levels and Predict Measures of Cognitive Function","abstract":"BACKGROUND: α-klotho might play a role in neurodegenerative diseases. OBJECTIVE: To determine levels of α-klotho and apoE in serum and cerebrospinal fluid (CSF) samples and their relationship with the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating (CDR). METHODS: All subjects were between age 39 to 83+ (n = 94). CDR and MMSE were administered to all participants. CSF was collected in the early afternoon by lumbar puncture. RESULTS: Serum and CSF levels of α-klotho are positively correlated and both predict scores on the MMSE and CDR, regardless of sex or apoE4 status. CONCLUSION: Our results demonstrate that α-klotho may be an important biomarker of cognitive health and neurodegeneration, and that relatively non-invasive sampling of α-klotho from serum is likely highly reflective of CSF levels.","journal":"Journal of Alzheimer s Disease","year":2022,"id":239680,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":48,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9168,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":426563,"name":"Benjamin Zimmerman","orcid":"0000-0003-2570-8198","position":1,"is_corresponding":false},{"id":226068,"name":"Joseph F. Quinn","orcid":"0000-0001-7305-2256","position":2,"is_corresponding":false},{"id":55003,"name":"Jeffrey Kaye","orcid":"0000-0002-9971-3478","position":3,"is_corresponding":false},{"id":325849,"name":"Nora Mattek","orcid":"0000-0003-2623-1969","position":4,"is_corresponding":false},{"id":446611,"name":"Shawn K. Westaway","orcid":null,"position":5,"is_corresponding":false},{"id":228247,"name":"Jacob Raber","orcid":"0000-0002-9861-9893","position":6,"is_corresponding":false},{"id":427478,"name":"Payel Kundu","orcid":null,"position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T00:22:41.699779Z","pmid":"35213382","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}