{"doi":"10.3233/jad-215671","title":"Carotid Intima-Media Thickness and Amyloid-β Deposition: The ARIC-PET Study","abstract":"We assessed whether carotid intima-media thickness (cIMT) is prospectively associated with amyloid-β (Aβ). 332 nondemented Atherosclerosis Risk in Communities Study participants with carotid ultrasounds (1990-1992) and PET scans (2012-2014) were studied. Participants in the highest (versus lowest) cIMT tertile had 2.17 times the odds of elevated Aβ (95% CI: 1.15-4.11), after demographic and APOE ɛ4 adjustments. An interaction with APOE ɛ4 was observed (p = 0.02). Greater cIMT was associated with elevated Aβ independent of vascular risk factors among those with ≥1 APOE ɛ4 allele, but not in noncarriers. In this cohort, higher cIMT was associated with Aβ deposition 22 years later, particularly among APOE ɛ4 carriers.","journal":"Journal of Alzheimer s Disease","year":2022,"id":279598,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":328345,"name":"Rebecca F. Gottesman","orcid":"0000-0002-9504-1256","position":1,"is_corresponding":false},{"id":350068,"name":"Michelle L. Meyer","orcid":"0000-0001-7085-3154","position":2,"is_corresponding":false},{"id":325846,"name":"Timothy M. Hughes","orcid":"0000-0002-2919-7199","position":3,"is_corresponding":false},{"id":623130,"name":"Kevin Sullivan","orcid":"0000-0001-9147-0988","position":4,"is_corresponding":false},{"id":342706,"name":"Dean F. Wong","orcid":"0000-0001-9343-8367","position":5,"is_corresponding":false},{"id":366482,"name":"Kamakshi Lakshminarayan","orcid":"0000-0002-8564-8986","position":6,"is_corresponding":false},{"id":98923,"name":"Pamela L. Lutsey","orcid":"0000-0002-1572-1340","position":7,"is_corresponding":false},{"id":443418,"name":"Wendy Wang","orcid":"0000-0001-6025-0173","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T00:28:55.546964Z","pmid":"35527548","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}