{"doi":"10.3233/jad-201349","title":"The Utility of Assessing Health-Related Quality of Life to Predict Cognitive Decline and Dementia","abstract":"BACKGROUND: Health-related quality of life (HRQoL) has been shown to predict adverse health outcome in the general population. OBJECTIVE: We examined the cross-sectional association between HRQoL and cognitive performance at baseline. Next, we explored whether baseline HRQoL predicted 5-year incident cognitive decline and dementia and whether there were gender differences. METHODS: 19,106 community-dwelling participants from the ASPirin in Reducing Events in the Elderly (ASPREE) trial, aged 65-98 years, free of major cognitive impairments, and completed the HRQoL 12-item short-form (SF-12) at baseline (2010-2014), were followed until June 2017. The physical (PCS) and mental component scores (MCS) of SF-12 were calculated. The cognitive tests were assessed at baseline, year 1, 3, 5, and 7 or close-out visit. Cognitive decline was defined as > 1.5 SD drop from baseline on any of the cognitive tests. Dementia was adjudicated according to DSM-IV criteria. Linear and Cox proportional-hazards regressions were used to examine the cross-sectional and longitudinal associations respectively. RESULTS: At baseline, higher PCS and MCS were associated with better cognition. Over a median 4.7-year follow-up, higher MCS was associated with a reduced risk of cognitive decline and dementia (12% and 15% respectively, per 10-unit increase) and a 10-unit higher PCS was associated with a 6% decreased risk of cognitive decline. PCS did not predict dementia incidence. Findings were not different by gender. CONCLUSION: Our study found that higher HRQoL, in particular MCS, predicted a reduced risk of cognitive decline and dementia over time in community-dwelling older people.","journal":"Journal of Alzheimer s Disease","year":2021,"id":168380,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7466,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":698551,"name":"on behalf of the ASPREE Investigator Group","orcid":null,"position":1,"is_corresponding":false},{"id":686180,"name":"David Alejandro González‐Chica","orcid":"0000-0002-7153-2878","position":2,"is_corresponding":false},{"id":404574,"name":"Nigel Stocks","orcid":"0000-0002-9018-0361","position":3,"is_corresponding":false},{"id":323248,"name":"Elsdon Storey","orcid":"0000-0001-5887-3267","position":4,"is_corresponding":false},{"id":264292,"name":"Robyn L. Woods","orcid":"0000-0003-1249-6149","position":5,"is_corresponding":false},{"id":104607,"name":"Anne M. Murray","orcid":"0000-0002-2787-8433","position":6,"is_corresponding":false},{"id":351162,"name":"Suzanne G. Orchard","orcid":"0000-0003-0211-3183","position":7,"is_corresponding":false},{"id":284810,"name":"Raj C. Shah","orcid":"0000-0001-9706-9730","position":8,"is_corresponding":false},{"id":689,"name":"Danijela Gašević","orcid":"0000-0001-5976-4011","position":9,"is_corresponding":false},{"id":686181,"name":"Rosanne Freak‐Poli","orcid":"0000-0003-4072-8699","position":10,"is_corresponding":false},{"id":332013,"name":"Joanne Ryan","orcid":"0000-0002-7039-6325","position":11,"is_corresponding":false},{"id":686179,"name":"Aung Zaw Zaw Phyo","orcid":"0000-0002-8834-4072","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-18T23:46:06.853307Z","pmid":"33579847","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}