{"doi":"10.3233/jad-2010-100141","title":"APOE Genotype Results in Differential Effects on the Peripheral Clearance of Amyloid-β42 in APOE Knock-in and Knock-out Mice","abstract":null,"journal":"Journal of Alzheimer's Disease","year":2010,"id":590247,"datarank":2.14519650153592,"base_score":4.02535169073515,"endowment":4.02535169073515,"self_citation_contribution":0.6038027536102726,"citation_network_contribution":1.5413937479256474,"self_endowment_contribution":0.6038027536102726,"citer_contribution":1.5413937479256474,"corpus_percentile":null,"corpus_rank":null,"citation_count":55,"citer_count":46,"citers_with_citation_signal":43,"citers_with_endowment":43,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1510227,"name":"Michael Morici","orcid":null,"position":1,"is_corresponding":false},{"id":236158,"name":"Eugene Hone","orcid":"0000-0001-6708-3718","position":2,"is_corresponding":false},{"id":1399838,"name":"Tamar Berger","orcid":null,"position":3,"is_corresponding":false},{"id":236157,"name":"Kevin Taddei","orcid":"0000-0002-8106-7957","position":4,"is_corresponding":false},{"id":1510228,"name":"Ian J. Martins","orcid":null,"position":5,"is_corresponding":false},{"id":1510229,"name":"Wei Ling F. Lim","orcid":null,"position":6,"is_corresponding":false},{"id":1510230,"name":"Sajla Singh","orcid":null,"position":7,"is_corresponding":false},{"id":13012,"name":"Markus R. Wenk","orcid":"0000-0001-5447-7881","position":8,"is_corresponding":false},{"id":270074,"name":"Jorge Ghiso","orcid":"0000-0002-0870-0437","position":9,"is_corresponding":false},{"id":35461,"name":"Joseph D. Buxbaum","orcid":"0000-0001-8898-8313","position":10,"is_corresponding":false},{"id":244537,"name":"Sam Gandy","orcid":"0000-0001-6455-4721","position":11,"is_corresponding":false},{"id":226618,"name":"Ralph N. Martins","orcid":"0000-0002-4828-9363","position":12,"is_corresponding":false},{"id":1510226,"name":"Matthew J. Sharman","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"APOE Genotype Results in Differential Effects on the Peripheral Clearance of Amyloid-β42 in APOE Knock-in and Knock-out Mice","abstract":"The epsilon4 allele of apolipoprotein E (APOE) is currently the major genetic risk factor identified for Alzheimer's disease (AD). Previous in vivo data from our laboratory has demonstrated that amyloid-beta (Abeta) is rapidly removed from the plasma by the liver and kidney and that the rate of its clearance is affected by ApoE in C57BL/6J and APOE-/- mice. To expand upon these findings, we assessed the peripheral clearance of human synthetic Abeta42 in APOE epsilon2, epsilon3, and epsilon4 knock-in and APOE knock-out mice injected with lipidated recombinant apoE2, E3, and E4 protein. Our results show that APOE does influence the rate at which the mice are able to clear Abeta42 from their bloodstream. Both APOE epsilon4 mice and APOE knock-out mice treated with lipidated recombinant apoE4 demonstrated increased retention of plasma Abeta42 over time compared to APOE epsilon2/APOE knock-out rE2 and APOE epsilon3/APOE knock-out rE3 mice. These findings suggest that the peripheral clearance of Abeta42 is significantly altered by APOE genotype. Given that APOE epsilon4 is a risk factor for AD, then these novel findings provide some insight into the role of ApoE isoforms on the peripheral clearance of Abeta which may impact on clearance from the brain.","is_dataset_classified":null,"base_score":4.02535169073515,"endowment":4.02535169073515,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20555142","pmcid":"PMC3292909","openalex_id":"https://openalex.org/W1882000658","authors":[],"funders":[{"funder_name":"NIA NIH HHS","grant_id":"AG10491","title":null},{"funder_name":"NIA NIH HHS","grant_id":"P01 AG010491","title":null}],"total_grants":2,"fwci":2.9256,"citation_percentile":0.90260141,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":7},{"year":2014,"count":6},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2017,"count":3},{"year":2018,"count":2},{"year":2019,"count":3},{"year":2020,"count":5},{"year":2021,"count":4},{"year":2022,"count":3},{"year":2023,"count":3},{"year":2024,"count":5},{"year":2025,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://content.iospress.com/download?id=10.3233/JAD-2010-100141","host_type":"publisher"},{"url":"https://doi.org/10.3233/jad-2010-100141","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20555142","host_type":"repository"},{"url":"http://ecite.utas.edu.au/78896","host_type":"repository"},{"url":"https://research-repository.uwa.edu.au/en/publications/a0b0c6fe-6727-412e-b1b7-3aba9964b5de","host_type":"repository"},{"url":"https://ro.ecu.edu.au/ecuworks/6446","host_type":"journal"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3292909","host_type":"repository"}],"fields_of_study":["Alzheimer's disease research and treatments","Cholinesterase and Neurodegenerative Diseases","Drug Transport and Resistance Mechanisms","Alzheimer Disease","Amyloid beta-Peptides","Animals","Apolipoprotein E2","Apolipoprotein E3","Apolipoprotein E4","Brain","Gene Knock-In Techniques","Genotype","Humans","Mice","Mice, 129 Strain","Mice, Inbred C57BL","Mice, Knockout","Peptide Fragments","Recombinant Proteins","Tissue Distribution"],"mesh_terms":["Alzheimer Disease","Animals","Brain","Genotype","Humans","Mice, Inbred C57BL","Peptide Fragments","Recombinant Proteins","Tissue Distribution","Amyloid beta-Peptides","Mice, Knockout","Mice","Apolipoprotein E3","Apolipoprotein E4","Apolipoprotein E2","Gene Knock-In Techniques","Mice, 129 Strain"],"keywords":["Apolipoprotein E","Gene knockin","Recombinant DNA","Knockout mouse","Amyloid (mycology)","Genotype","Allele","Phenotype","Peripheral","Internal medicine","Biology","Medicine","Endocrinology","Disease","Pathology","Receptor","Genetics","Gene"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.22619233.v1","title":"Additional file 1 of Plasma β2-microglobulin and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact older adults: the CABLE study","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.22619233","title":"Additional file 1 of Plasma β2-microglobulin and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact older adults: the CABLE study","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-24T15:00:14.911308Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}