{"doi":"10.3233/jad-200959","title":"Physical Activity and Trajectory of Cognitive Change in Older Persons: Mayo Clinic Study of Aging","abstract":"BACKGROUND: Little is known about the association between physical activity (PA) and cognitive trajectories in older adults. OBJECTIVE: To examine the association between PA and change in memory, language, attention, visuospatial skills, and global cognition, and a potential impact of sex or Apolipoprotein E (APOE) ɛ4 status. METHODS: Longitudinal study derived from the population-based Mayo Clinic Study of Aging, including 2,060 cognitively unimpaired males and females aged ≥70 years. Engagement in midlife (ages 50-65) and late-life (last year) PA was assessed using a questionnaire. Neuropsychological testing was done every 15 months (mean follow-up 5.8 years). We ran linear mixed-effect models to examine whether mid- or late-life PA at three intensities (mild, moderate, vigorous) was associated with cognitive z-scores. RESULTS: Light intensity midlife PA was associated with less decline in memory function compared to the no-PA reference group (time x light PA; estimate [standard error] 0.047 [0.016], p = 0.004). Vigorous late-life PA was associated with less decline in language (0.033 [0.015], p = 0.030), attention (0.032 [0.017], p = 0.050), and global cognition (0.039 [0.016], p = 0.012). Females who were physically inactive in midlife experienced more pronounced cognitive decline than females physically active in midlife and males regardless of PA (p-values for time interaction terms with midlife PA levels and sex were all p < 0.05 for global cognition). APOE ɛ4 carriership did not moderate the association between PA and cognition. CONCLUSION: Engaging in PA, particularly of vigorous intensity in late-life, was associated with less pronounced decline in global and domain-specific cognition. This association may differ by sex.","journal":"Journal of Alzheimer s Disease","year":2020,"id":101912,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8707,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":253902,"name":"Jeremy A. Syrjanen","orcid":"0000-0001-5990-8206","position":1,"is_corresponding":false},{"id":498660,"name":"Jelena Bezold","orcid":null,"position":2,"is_corresponding":false},{"id":498123,"name":"Sandra Trautwein","orcid":"0000-0002-1874-0723","position":3,"is_corresponding":false},{"id":498124,"name":"Bettina Barisch‐Fritz","orcid":"0000-0003-4801-2310","position":4,"is_corresponding":false},{"id":498661,"name":"Klaus Boes","orcid":null,"position":5,"is_corresponding":false},{"id":250628,"name":"Alexander Wöll","orcid":"0000-0002-5736-2980","position":6,"is_corresponding":false},{"id":392194,"name":"Erica Forzani","orcid":"0000-0003-2407-8251","position":7,"is_corresponding":false},{"id":253903,"name":"Walter K. Kremers","orcid":"0000-0001-5714-3473","position":8,"is_corresponding":false},{"id":259156,"name":"Mary M. Machulda","orcid":"0000-0003-4834-5967","position":9,"is_corresponding":false},{"id":228538,"name":"Michelle M. Mielke","orcid":"0000-0001-7177-1185","position":10,"is_corresponding":false},{"id":49955,"name":"David S. Knopman","orcid":"0000-0002-6544-066X","position":11,"is_corresponding":false},{"id":27599,"name":"Ronald C. Petersen","orcid":"0000-0002-8178-6601","position":12,"is_corresponding":false},{"id":461079,"name":"Maria Vassilaki","orcid":"0000-0001-8328-136X","position":13,"is_corresponding":false},{"id":461080,"name":"Yonas E. Geda","orcid":"0000-0003-1187-7230","position":14,"is_corresponding":false},{"id":461078,"name":"Janina Krell‐Roesch","orcid":"0000-0003-4011-9842","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-18T22:40:22.678835Z","pmid":"33216032","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}