{"doi":"10.3233/jad-170788","title":"Nature of Tau-Associated Neurodegeneration and the Molecular Mechanisms","abstract":"<jats:p>Neurodegeneration is defined as the progressive loss of structure or function of the neurons. As the nature of degenerative cell loss is currently not clear, there is no specific molecular marker to measure neurodegeneration. Therefore, researchers have been using apoptotic markers to measure neurodegeneration. However, neurodegeneration is completely different from apoptosis by morphology and time course. Lacking specific molecular marker has been the major hindrance in research of neurodegenerative disorders. Alzheimer’s disease (AD) is the most common neurodegenerative disorder, and tau accumulation forming neurofibrillary tangles is a hallmark pathology in the AD brains, suggesting that tau must play a critical role in AD neurodegeneration. Here we review part of our published papers on tau-related studies, and share our thoughts on the nature of tau-associated neurodegeneration in AD.</jats:p>","journal":"Journal of Alzheimer’s Disease","year":2018,"id":590850,"datarank":1.8219123255290555,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"self_citation_contribution":0.5775221402565088,"citation_network_contribution":1.2443901852725467,"self_endowment_contribution":0.5775221402565088,"citer_contribution":1.2443901852725467,"corpus_percentile":null,"corpus_rank":null,"citation_count":46,"citer_count":42,"citers_with_citation_signal":38,"citers_with_endowment":38,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1511653,"name":"Jian-Zhi Wang","orcid":null,"position":1,"is_corresponding":false},{"id":757441,"name":"Ying Yang","orcid":"0000-0003-2378-6889","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Nature of Tau-Associated Neurodegeneration and the Molecular Mechanisms","abstract":"<jats:p>Neurodegeneration is defined as the progressive loss of structure or function of the neurons. As the nature of degenerative cell loss is currently not clear, there is no specific molecular marker to measure neurodegeneration. Therefore, researchers have been using apoptotic markers to measure neurodegeneration. However, neurodegeneration is completely different from apoptosis by morphology and time course. Lacking specific molecular marker has been the major hindrance in research of neurodegenerative disorders. Alzheimer’s disease (AD) is the most common neurodegenerative disorder, and tau accumulation forming neurofibrillary tangles is a hallmark pathology in the AD brains, suggesting that tau must play a critical role in AD neurodegeneration. Here we review part of our published papers on tau-related studies, and share our thoughts on the nature of tau-associated neurodegeneration in AD.</jats:p>","is_dataset_classified":null,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29562535","pmcid":"PMC5870018","openalex_id":"https://openalex.org/W2794217300","authors":[],"funders":[],"total_grants":0,"fwci":2.6432,"citation_percentile":0.90319652,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":4},{"year":2020,"count":7},{"year":2021,"count":9},{"year":2022,"count":7},{"year":2023,"count":7},{"year":2024,"count":5},{"year":2025,"count":3},{"year":2026,"count":3}],"oa_status":"hybrid","license":"cc-by-nc","oa_locations":[{"url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad170788?id=journal-of-alzheimers-disease%2Fjad170788","host_type":"journal"},{"url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad170788?id=journal-of-alzheimers-disease%2Fjad170788","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/pdf/10.3233/JAD-170788","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/full-xml/10.3233/JAD-170788","host_type":"publisher"},{"url":"https://doi.org/10.3233/jad-170788","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29562535","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5870018","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5870018","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5870018?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Alzheimer's disease research and treatments","Neuroscience and Neuropharmacology Research","Neuroinflammation and Neurodegeneration Mechanisms","Animals","Humans","Nerve Degeneration","Neurodegenerative Diseases","tau Proteins"],"mesh_terms":["Animals","Humans","Nerve Degeneration","tau Proteins","Neurodegenerative Diseases"],"keywords":["Neurodegeneration","Neuroscience","Psychology","Disease","Medicine","Pathology","Apoptosis","Tau","Alzheimer’s disease","Neurodegenerasis"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.24546913.v1","title":"Additional file 1 of A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.24546913","title":"Additional file 1 of A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-25T12:42:31.346589Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}