{"doi":"10.3233/jad-121927","title":"Amyloid Deposition in Early Onset versus Late Onset Alzheimer's Disease","abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:</jats:title>\n                    <jats:p>Patients with early-onset Alzheimer’s disease (EOAD) may differ from those with late-onset Alzheimer’s disease (LOAD) in cognitive impairment profiles and clinical course. Postmortem studies also reported that EOAD has a greater pathologic burden than LOAD. We examined the effects of age at onset on the burden and distribution of amyloid plaques in patients with AD, using a statistical parametric mapping (SPM) and regions of interest (ROIs) analyses of the Pittsburgh compound B (PiB)-PET.</jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:</jats:title>\n                    <jats:p>\n                      We initially recruited 72 patients with AD who had completed the [\n                      <jats:sup>11</jats:sup>\n                      C] PiB-PET scan, but four patients were excluded due to familial AD or incomplete MRI data. Of the 68 patients, 61 were classified as PiB-positive (PiB+) and seven as PiB-negative (PiB–) using the measured global PiB uptake ratio values. Of the 61 patients with PiB+ AD, in order to maximize the effect of onset age, we excluded 20 patients in their 60 s. Thus among the remaining 41 patients, the amyloid deposition of only 17 patients with EOAD (age onset &lt;60 years) and 24 patients with LOAD (onset age ≥70 years) were compared.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:</jats:title>\n                    <jats:p>There were no significant differences in the global mean PiB index between EOAD and LOAD patients, whereas SPM and ROIs analyses showed that those with EOAD retained higher levels of PiB in the bilateral basal ganglia, bilateral thalamus, left superior temporal cortex, and left cuneus compared to those with LOAD.</jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusion:</jats:title>\n                    <jats:p>Our findings demonstrated that EOAD patients differed from those with LOAD in the topography of amyloid deposition, which may partly account for the findings from previous studies that extrapyramidal symptoms and frontal dysfunction are more common in EOAD than in LOAD patients.</jats:p>\n                  </jats:sec>","journal":"Journal of Alzheimer’s Disease","year":2013,"id":644342,"datarank":2.653331918246496,"base_score":4.219507705176107,"endowment":4.219507705176107,"self_citation_contribution":0.6329261557764161,"citation_network_contribution":2.0204057624700797,"self_endowment_contribution":0.6329261557764161,"citer_contribution":2.0204057624700797,"corpus_percentile":null,"corpus_rank":null,"citation_count":67,"citer_count":55,"citers_with_citation_signal":49,"citers_with_endowment":49,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":300908,"name":"Sang Won Seo","orcid":"0000-0002-8747-0122","position":1,"is_corresponding":false},{"id":112093,"name":"Jung-Hyun Kim","orcid":null,"position":2,"is_corresponding":false},{"id":1677062,"name":"Mee Kyung Suh","orcid":null,"position":3,"is_corresponding":false},{"id":178481,"name":"Jae-Hong Lee","orcid":null,"position":4,"is_corresponding":false},{"id":1010512,"name":"Yearn Seong Choe","orcid":"0000-0002-5164-9809","position":5,"is_corresponding":false},{"id":1677063,"name":"Kyung-Han Lee","orcid":null,"position":6,"is_corresponding":false},{"id":886678,"name":"Jae Seung Kim","orcid":"0000-0003-1710-1185","position":7,"is_corresponding":false},{"id":1677064,"name":"Geon Ha Kim","orcid":null,"position":8,"is_corresponding":false},{"id":867213,"name":"Young Noh","orcid":"0000-0002-9633-3314","position":9,"is_corresponding":false},{"id":1403281,"name":"Byoung Seok Ye","orcid":"0000-0003-0187-8440","position":10,"is_corresponding":false},{"id":699589,"name":"Hee Jin Kim","orcid":"0000-0002-0128-2789","position":11,"is_corresponding":false},{"id":1677065,"name":"Cindy W. Yoon","orcid":null,"position":12,"is_corresponding":false},{"id":1109773,"name":"Juhee Chin","orcid":"0000-0002-3784-9716","position":13,"is_corresponding":false},{"id":694170,"name":"Duk L. Na","orcid":"0000-0002-0098-7592","position":14,"is_corresponding":false},{"id":1272283,"name":"Hanna Cho","orcid":"0000-0001-6298-0997","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Amyloid Deposition in Early Onset versus Late Onset Alzheimer's Disease","abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:</jats:title>\n                    <jats:p>Patients with early-onset Alzheimer’s disease (EOAD) may differ from those with late-onset Alzheimer’s disease (LOAD) in cognitive impairment profiles and clinical course. Postmortem studies also reported that EOAD has a greater pathologic burden than LOAD. We examined the effects of age at onset on the burden and distribution of amyloid plaques in patients with AD, using a statistical parametric mapping (SPM) and regions of interest (ROIs) analyses of the Pittsburgh compound B (PiB)-PET.</jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:</jats:title>\n                    <jats:p>\n                      We initially recruited 72 patients with AD who had completed the [\n                      <jats:sup>11</jats:sup>\n                      C] PiB-PET scan, but four patients were excluded due to familial AD or incomplete MRI data. Of the 68 patients, 61 were classified as PiB-positive (PiB+) and seven as PiB-negative (PiB–) using the measured global PiB uptake ratio values. Of the 61 patients with PiB+ AD, in order to maximize the effect of onset age, we excluded 20 patients in their 60 s. Thus among the remaining 41 patients, the amyloid deposition of only 17 patients with EOAD (age onset &lt;60 years) and 24 patients with LOAD (onset age ≥70 years) were compared.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:</jats:title>\n                    <jats:p>There were no significant differences in the global mean PiB index between EOAD and LOAD patients, whereas SPM and ROIs analyses showed that those with EOAD retained higher levels of PiB in the bilateral basal ganglia, bilateral thalamus, left superior temporal cortex, and left cuneus compared to those with LOAD.</jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusion:</jats:title>\n                    <jats:p>Our findings demonstrated that EOAD patients differed from those with LOAD in the topography of amyloid deposition, which may partly account for the findings from previous studies that extrapyramidal symptoms and frontal dysfunction are more common in EOAD than in LOAD patients.</jats:p>\n                  </jats:sec>","is_dataset_classified":null,"base_score":4.219507705176107,"endowment":4.219507705176107,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23507771","pmcid":null,"openalex_id":"https://openalex.org/W1569623282","authors":[],"funders":[],"total_grants":0,"fwci":2.4082,"citation_percentile":0.8757112,"influential_citations":0,"citation_trend":[{"year":2014,"count":2},{"year":2015,"count":8},{"year":2016,"count":3},{"year":2017,"count":8},{"year":2018,"count":7},{"year":2019,"count":4},{"year":2020,"count":6},{"year":2021,"count":8},{"year":2022,"count":7},{"year":2023,"count":4},{"year":2024,"count":5},{"year":2025,"count":2},{"year":2026,"count":3}],"oa_status":"green","license":"cc-by-nc-nd","oa_locations":[{"url":"https://content.iospress.com/articles/journal-of-alzheimers-disease/jad121927","host_type":"repository"},{"url":"https://content.iospress.com/articles/journal-of-alzheimers-disease/jad121927","host_type":"repository"},{"url":"https://journals.sagepub.com/doi/pdf/10.3233/JAD-121927","host_type":"publisher"},{"url":"https://doi.org/10.3233/jad-121927","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23507771","host_type":"repository"}],"fields_of_study":["Dementia and Cognitive Impairment Research","Alzheimer's disease research and treatments","Neurological and metabolic disorders"],"mesh_terms":["Aged","Aged, 80 and over","Alzheimer Disease","Amyloid","Aniline Compounds","Data Interpretation, Statistical","Female","Genotype","Humans","Image Processing, Computer-Assisted","Magnetic Resonance Imaging","Male","Middle Aged","Neuropsychological Tests","Psychomotor Performance","Thiazoles","Age of Onset","Sample Size","Radiopharmaceuticals","Positron-Emission Tomography","Apolipoprotein E4"],"keywords":["Pittsburgh compound B","Early-onset Alzheimer's disease","Cardiology","Medicine","Internal medicine","Alzheimer's disease","Cuneus","Age of onset","Statistical parametric mapping","Pathology","Disease","Magnetic resonance imaging","Precuneus","Radiology","Cognition","Psychiatry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T00:56:58.283619Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}