{"doi":"10.3233/ch-211109","title":"Examination of the relation between red blood cell aggregation and hematocrit in human and various experimental animals","abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>BACKGROUND:</jats:title>\n                    <jats:p>Red blood cell (RBC) aggregation plays an important role in the physiological processes of the microcirculation. The complete mechanism of aggregation is still unclear, and it is influenced by several cellular and plasmatic factors. One of these factors is the hematocrit (Hct).</jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>OBJECTIVE:</jats:title>\n                    <jats:p>We hypothesized that the relation of RBC aggregation and Hct differs between species.</jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>METHODS:</jats:title>\n                    <jats:p>From anticoagulated blood samples of healthy volunteers, rats, dogs, and pigs, 20, 40, and 60 %Hct RBC, autologous plasma suspensions were prepared. Hematological parameters and RBC aggregation was determined by light-transmission and light-reflection method.</jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>RESULTS:</jats:title>\n                    <jats:p>Suspensions at 20%and 60%Hct expressed lower RBC aggregation than of 40%Hct suspensions, showing inter-species differences. By curve fitting the Hct at the highest aggregation value differed in species (human: 45.25%- M 5 s, 40.86%- amp; rat: 44.44 %- M1 10 s, 39.37%- amp; dog: 42.48%- M 5 s, 44.29%- amp; pig: 47.63%- M 5 s, 52.8%- amp).</jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>CONCLUSION:</jats:title>\n                    <jats:p>RBC aggregation - hematocrit relation shows inter-species differences. Human blood was found to be the most sensitive for hematocrit changes. The more obvious differences could be detected by M 5 s by light-transmission method and amplitude parameter using light-reflection method.</jats:p>\n                  </jats:sec>","journal":"Clinical Hemorheology and Microcirculation","year":2021,"id":651920,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1700416,"name":"Viktoria Somogyi","orcid":null,"position":1,"is_corresponding":false},{"id":1700417,"name":"Bence Tanczos","orcid":null,"position":2,"is_corresponding":false},{"id":1700418,"name":"Adam Varga","orcid":null,"position":3,"is_corresponding":false},{"id":1700419,"name":"Zsuzsanna Bereczky","orcid":null,"position":4,"is_corresponding":false},{"id":1700420,"name":"Norbert Nemeth","orcid":null,"position":5,"is_corresponding":false},{"id":1700422,"name":"Adam Deak","orcid":null,"position":6,"is_corresponding":false},{"id":1700414,"name":"Barbara Barath","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Examination of the relation between red blood cell aggregation and hematocrit in human and various experimental animals","abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>BACKGROUND:</jats:title>\n                    <jats:p>Red blood cell (RBC) aggregation plays an important role in the physiological processes of the microcirculation. The complete mechanism of aggregation is still unclear, and it is influenced by several cellular and plasmatic factors. One of these factors is the hematocrit (Hct).</jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>OBJECTIVE:</jats:title>\n                    <jats:p>We hypothesized that the relation of RBC aggregation and Hct differs between species.</jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>METHODS:</jats:title>\n                    <jats:p>From anticoagulated blood samples of healthy volunteers, rats, dogs, and pigs, 20, 40, and 60 %Hct RBC, autologous plasma suspensions were prepared. Hematological parameters and RBC aggregation was determined by light-transmission and light-reflection method.</jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>RESULTS:</jats:title>\n                    <jats:p>Suspensions at 20%and 60%Hct expressed lower RBC aggregation than of 40%Hct suspensions, showing inter-species differences. By curve fitting the Hct at the highest aggregation value differed in species (human: 45.25%- M 5 s, 40.86%- amp; rat: 44.44 %- M1 10 s, 39.37%- amp; dog: 42.48%- M 5 s, 44.29%- amp; pig: 47.63%- M 5 s, 52.8%- amp).</jats:p>\n                  </jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>CONCLUSION:</jats:title>\n                    <jats:p>RBC aggregation - hematocrit relation shows inter-species differences. Human blood was found to be the most sensitive for hematocrit changes. The more obvious differences could be detected by M 5 s by light-transmission method and amplitude parameter using light-reflection method.</jats:p>\n                  </jats:sec>","is_dataset_classified":null,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33579832","pmcid":null,"openalex_id":"https://openalex.org/W3126276609","authors":[],"funders":[],"total_grants":0,"fwci":1.0431,"citation_percentile":0.76255279,"influential_citations":0,"citation_trend":[{"year":2022,"count":3},{"year":2023,"count":2},{"year":2024,"count":3},{"year":2025,"count":5}],"oa_status":"green","license":"other-oa","oa_locations":[{"url":"http://hdl.handle.net/2437/302268","host_type":"repository"},{"url":"http://hdl.handle.net/2437/302268","host_type":"repository"},{"url":"https://journals.sagepub.com/doi/pdf/10.3233/CH-211109","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/full-xml/10.3233/CH-211109","host_type":"publisher"},{"url":"https://doi.org/10.3233/ch-211109","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33579832","host_type":"repository"},{"url":"http://hdl.handle.net/2437/302269","host_type":"repository"}],"fields_of_study":["Blood properties and coagulation","Erythrocyte Function and Pathophysiology","Clinical Laboratory Practices and Quality Control"],"mesh_terms":["Adult","Animals","Blood Coagulation","Blood Viscosity","Dogs","Erythrocyte Aggregation","Erythrocytes","Hematocrit","Humans","Male","Microcirculation","Swine","Hemorheology","Rats"],"keywords":["Hematocrit","Red blood cell","Medicine","Agrégation","Red Cell","Blood cell","Immunology","Internal medicine","Hemorheology","Red Blood Cell Aggregation","Inter-species Differences"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T11:15:02.644732Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}