{"doi":"10.3233/cbm-230431","title":"Circulating tumor DNA (ctDNA) as a biomarker of response to therapy in advanced Hepatocellular carcinoma treated with Nivolumab","abstract":"BACKGROUND: Circulating tumor DNA (ctDNA) is a promising non-invasive marker for detection, diagnosis, treatment selection, and prognosis of hepatocellular carcinoma (HCC). OBJECTIVE: This study aimed to examine the utility of ctDNA as a prognostic and predictive tool in HCC patients treated with nivolumab. METHODS: We analyzed pre-treatment ctDNA from 44 HCC patients using comprehensive genomic testing on a commercially available platform. We utilized log rank test and univariate Cox models to correlate overall survival (OS) and progression-free survival (PFS) with ctDNA expressions. RESULTS: Of 44 patients, 77.3% were men with median age of 67 years. All but 3 patients had at least one alteration identified, and TP53 was the most commonly altered gene (52.3%). Median OS was 17.5 months (95% CI: 12.7, NA). Mutations involving PIK3CA, BRCA1, and CCND1 amplification were associated with shorter OS (P 0.0001, 0.0001 and 0.01, respectively). Median PFS time was 4.01 months (95% CI: 3.06, 9.33). Mutations involving KIT and PIK3CA were associated with shorter PFS (P 0.0001 and 0.0004, respectively), while mutation involving CTNNB1 were associated with longer PFS (p= 0.04). CONCLUSIONS: ctDNA profiling may provide a benefit for prediction of survival and progression of HCC patients treated with nivolumab. Future studies are needed for confirmation.","journal":"Cancer Biomarkers","year":2024,"id":435747,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9516,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":573504,"name":"Sunyoung S. Lee","orcid":"0000-0002-5954-5991","position":1,"is_corresponding":false},{"id":1243367,"name":"Tarık Demir","orcid":"0000-0001-6334-4079","position":2,"is_corresponding":false},{"id":911594,"name":"Shadi Chamseddine","orcid":"0000-0001-7715-0689","position":3,"is_corresponding":false},{"id":861422,"name":"Zishuo Ian Hu","orcid":null,"position":4,"is_corresponding":false},{"id":419794,"name":"Lianchun Xiao","orcid":"0000-0003-0972-2766","position":5,"is_corresponding":false},{"id":542700,"name":"Khaled M. Elsayes","orcid":"0000-0003-0184-0717","position":6,"is_corresponding":false},{"id":261811,"name":"Jeffrey S. Morris","orcid":"0000-0002-8520-6088","position":7,"is_corresponding":false},{"id":395090,"name":"Robert A. Wolff","orcid":"0000-0002-6614-1610","position":8,"is_corresponding":false},{"id":794816,"name":"Rikita Hiatia","orcid":null,"position":9,"is_corresponding":false},{"id":573502,"name":"Aliya Qayyum","orcid":"0000-0003-1590-9041","position":10,"is_corresponding":false},{"id":65862,"name":"Asif Rashid","orcid":"0000-0001-8463-7321","position":11,"is_corresponding":false},{"id":238100,"name":"Dan G. Duda","orcid":"0000-0001-7065-8797","position":12,"is_corresponding":false},{"id":368861,"name":"James C. Yao","orcid":"0000-0002-1875-3962","position":13,"is_corresponding":false},{"id":1066022,"name":"Michael LaPelusa","orcid":"0000-0001-6078-0561","position":14,"is_corresponding":false},{"id":227744,"name":"Eugene J. Koay","orcid":"0000-0001-7675-3461","position":15,"is_corresponding":false},{"id":648307,"name":"Armeen Mahvash","orcid":"0000-0003-0416-4566","position":16,"is_corresponding":false},{"id":1243368,"name":"Ahmed Azzam","orcid":"0000-0002-1342-5425","position":17,"is_corresponding":false},{"id":266116,"name":"Ecaterina E. Dumbrava","orcid":"0000-0002-1959-0536","position":18,"is_corresponding":false},{"id":420932,"name":"Manal M. Hassan","orcid":"0000-0002-8413-449X","position":19,"is_corresponding":false},{"id":473838,"name":"Hesham M. Amin","orcid":"0000-0002-7973-6699","position":20,"is_corresponding":false},{"id":54196,"name":"Ahmed O. Kaseb","orcid":"0000-0002-9491-0587","position":21,"is_corresponding":false},{"id":573501,"name":"Yehia I. Mohamed","orcid":"0000-0002-5192-3804","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-19T02:00:08.103086Z","pmid":"39269823","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}