{"doi":"10.3233/adr-230052","title":"Exploring the Potential Association Between Self-Reported Psychological Stress and Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease in Midlife: A Cross-Sectional Study","abstract":"Psychological stress is associated with dementia risk. However, the underlying mechanisms are unclear. This cross-sectional study examined the association between self-reported psychological stress and cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease and neurodegeneration in 73 cognitively unimpaired middle-aged adults from the Healthy Brain Project (mean age = 58±7 years). Linear regression analyses did not reveal any significant associations of psychological stress with CSF amyloid-β 42 , phosphorylated tau-181, total tau, or neurofilament light chain. Cohen’s f 2 effect sizes were small in magnitude (f 2 ≤0.08). Further research is needed to replicate our findings, particularly given that the sample reported on average low levels of stress.","journal":"Journal of Alzheimer s Disease Reports","year":2023,"id":411348,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9199,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":968384,"name":"Lachlan Cribb","orcid":"0000-0001-5276-5249","position":1,"is_corresponding":false},{"id":709799,"name":"Lisa Bransby","orcid":"0000-0002-2846-6895","position":2,"is_corresponding":false},{"id":261846,"name":"Rachel F. Buckley","orcid":"0000-0002-5356-5537","position":3,"is_corresponding":false},{"id":249941,"name":"Nawaf Yassi","orcid":"0000-0002-0685-0060","position":4,"is_corresponding":false},{"id":792045,"name":"Trevor T.‐J. Chong","orcid":"0000-0001-7764-3811","position":5,"is_corresponding":false},{"id":301878,"name":"Yen Ying Lim","orcid":"0000-0002-0308-5156","position":6,"is_corresponding":false},{"id":350988,"name":"Matthew P. Pase","orcid":"0000-0002-4143-8485","position":7,"is_corresponding":false},{"id":1051057,"name":"Katherine H. Franks","orcid":"0000-0001-8635-216X","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":null,"created_at":"2026-07-19T01:21:42.971455Z","pmid":"37849635","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}