{"doi":"10.3233/adr-230043","title":"ADSS: A Composite Score to Detect Disease Progression in Alzheimer’s Disease","abstract":"Background: Composite scores have been increasingly used in trials for Alzheimer's disease (AD) to detect disease progression, such as the AD Composite Score (ADCOMS) in the lecanemab trial. Objective: To develop a new composite score to improve the prediction of outcome change. Methods: We proposed to develop a new composite score based on the statistical model in the ADCOMS, by removing duplicated sub-scales and adding the model selection in the partial least squares (PLS) regression. Results: election (ADSS) includes 7 cognitive sub-scales. ADSS can increase the sensitivity to detect disease progression as compared to the existing total scores, which leads to smaller sample sizes using the ADSS in trial designs. Conclusions: ADSS can be utilized in AD trials to improve the success rate of drug development with a high sensitivity to detect disease progression in early stages.","journal":"Journal of Alzheimer s Disease Reports","year":2024,"id":433656,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9592,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1137355,"name":"Xinlin Lu","orcid":"0000-0003-2956-921X","position":1,"is_corresponding":false},{"id":526588,"name":"Zhigang Li","orcid":"0000-0002-6224-1833","position":2,"is_corresponding":false},{"id":368383,"name":"Jessica Caldwell","orcid":"0000-0003-2849-2679","position":3,"is_corresponding":false},{"id":66882,"name":"Charles Bernick","orcid":"0000-0003-4040-3587","position":4,"is_corresponding":false},{"id":2716,"name":"Jeffrey L. Cummings","orcid":"0000-0001-8944-4158","position":5,"is_corresponding":false},{"id":419558,"name":"Guogen Shan","orcid":"0000-0001-8690-6599","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T01:59:49.434790Z","pmid":"38405343","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}