{"doi":"10.3233/adr-200253","title":"Aortic Valve Calcification Is Associated with Future Cognitive Impairment","abstract":"Background: While an association between atherosclerosis and dementia has been identified, few studies have assessed the longitudinal relationship between aortic valve calcification (AVC) and cognitive impairment (CI). Objective: We sought to determine whether AVC derived from lung cancer screening CT (LCSCT) was associated with CI in a moderate-to-high atherosclerotic risk cohort. Methods: This was a single site, retrospective analysis of 1401 U.S. veterans (65 years [IQI: 61, 68] years; 97%male) who underwent quantification of AVC from LCSCT indicated for smoking history. The primary outcome was new diagnosis of CI identified by objective testing (Mini-Mental Status Exam or Montreal Cognitive Assessment) or by ICD coding. Time-to-event analysis was carried out using AVC as a continuous variable. Results: Over 5 years, 110 patients (8%) were diagnosed with CI. AVC was associated with new diagnosis of CI using 3 Models for adjustment: 1) age (HR: 1.104; CI: 1.023–1.191; p = 0.011); 2) Model 1 plus hypertension, hyperlipidemia, diabetes, CKD stage 3 or higher (glomerular filtration rate < 60 mL/min) and CAD (HR: 1.097; CI: 1.014–1.186; p = 0.020); and 3) Model 2 plus CVA (HR: 1.094; CI: 1.011–1.182; p = 0.024). Sensitivity analysis demonstrated that the association between AVC and new diagnosis of CI remained significant upon exclusion of severe AVC (HR: 1.100 [ 1.013–1.194 ]; p = 0.023). Subgroup analysis demonstrated that this association remained significant when including education in the multivariate analysis (HR: 1.127 [ 1.030–1.233 ]; p = 0.009). Conclusion: This is the first study demonstrating that among mostly male individuals who underwent LCSCT, quantified aortic valve calcification is associated with new diagnosis of CI.","journal":"Journal of Alzheimer s Disease Reports","year":2021,"id":193777,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9315,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":762384,"name":"Jessica Chen","orcid":"0000-0001-5444-0130","position":1,"is_corresponding":false},{"id":477853,"name":"Dhairyasheel Ghosalkar","orcid":null,"position":2,"is_corresponding":false},{"id":332042,"name":"Jared Christensen","orcid":"0000-0002-7366-8357","position":3,"is_corresponding":false},{"id":476486,"name":"Alice Chu","orcid":"0000-0003-4099-580X","position":4,"is_corresponding":false},{"id":762385,"name":"Chris Mantsounga","orcid":"0000-0003-3494-9081","position":5,"is_corresponding":false},{"id":762846,"name":"Jade Neverson","orcid":null,"position":6,"is_corresponding":false},{"id":762386,"name":"Cullen Soares","orcid":"0000-0002-1108-7530","position":7,"is_corresponding":false},{"id":233769,"name":"Nishant R. Shah","orcid":"0000-0002-2929-5071","position":8,"is_corresponding":false},{"id":440205,"name":"Wen‐Chih Wu","orcid":"0000-0002-2834-2024","position":9,"is_corresponding":false},{"id":233770,"name":"Gaurav Choudhary","orcid":"0000-0001-9343-5481","position":10,"is_corresponding":false},{"id":82855,"name":"Alan Morrison","orcid":"0000-0002-2412-7669","position":11,"is_corresponding":false},{"id":476485,"name":"Hojune Chung","orcid":"0000-0002-0146-7222","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-18T23:49:51.300073Z","pmid":"34113789","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}