{"doi":"10.3201/eid2910.230181","title":"<i>Candida auris</i> Clinical Isolates Associated with Outbreak in Neonatal Unit of Tertiary Academic Hospital, South Africa","abstract":"Candida auris was first detected at a university-affiliated hospital in Johannesburg, South Africa, in 2009. We used whole-genome sequencing to describe the molecular epidemiology of C. auris in the same hospital during 2016-2020; the neonatal unit had a persistent outbreak beginning in June 2019. Of 287 cases with culture-confirmed C. auris infection identified through laboratory surveillance, 207 (72%) had viable isolates and 188 (66%) were processed for whole-genome sequencing. Clade III (118/188, 63%) and IV (70/188, 37%) isolates co-circulated in the hospital. All 181/188 isolates that had a fluconazole MIC >32 µg/mL had ERG11 mutations; clade III isolates had VF125AL substitutions, and clade IV isolates had K177R/N335S/E343D substitutions. Dominated by clade III, the neonatal unit outbreak accounted for 32% (91/287) of all cases during the study period. The outbreak may have originated through transmission from infected or colonized patients, colonized healthcare workers, or contaminated equipment/environment.","journal":"Emerging infectious diseases","year":2023,"id":325174,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9071,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":473348,"name":"Serisha D. Naicker","orcid":"0000-0002-4445-1482","position":1,"is_corresponding":false},{"id":1042647,"name":"Liliwe Shuping","orcid":"0000-0002-1428-779X","position":2,"is_corresponding":false},{"id":462032,"name":"Sithembiso Velaphi","orcid":"0000-0002-9219-8485","position":3,"is_corresponding":false},{"id":1042648,"name":"Firdose Nakwa","orcid":"0000-0001-8884-2517","position":4,"is_corresponding":false},{"id":474250,"name":"Jeannette Wadula","orcid":null,"position":5,"is_corresponding":false},{"id":239834,"name":"Nelesh P. Govender","orcid":"0000-0001-7869-9462","position":6,"is_corresponding":false},{"id":1043353,"name":"for GERMS-SA1","orcid":null,"position":7,"is_corresponding":false},{"id":839033,"name":"Dikeledi Kekana","orcid":"0000-0003-2295-2099","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T01:08:22.919783Z","pmid":"37735719","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}