{"doi":"10.3201/eid2905.220796","title":"Use of High-Resolution Geospatial and Genomic Data to Characterize Recent Tuberculosis Transmission, Botswana","abstract":"Combining genomic and geospatial data can be useful for understanding Mycobacterium tuberculosis transmission in high-burden tuberculosis (TB) settings. We performed whole-genome sequencing on M. tuberculosis DNA extracted from sputum cultures from a population-based TB study conducted in Gaborone, Botswana, during 2012-2016. We determined spatial distribution of cases on the basis of shared genotypes among isolates. We considered clusters of isolates with ≤5 single-nucleotide polymorphisms identified by whole-genome sequencing to indicate recent transmission and clusters of ≥10 persons to be outbreaks. We obtained both molecular and geospatial data for 946/1,449 (65%) participants with culture-confirmed TB; 62 persons belonged to 5 outbreaks of 10-19 persons each. We detected geospatial clustering in just 2 of those 5 outbreaks, suggesting heterogeneous spatial patterns. Our findings indicate that targeted interventions applied in smaller geographic areas of high-burden TB identified using integrated genomic and geospatial data might help interrupt TB transmission during outbreaks.","journal":"Emerging infectious diseases","year":2023,"id":345926,"datarank":0.5435955262256592,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.15885312260642864,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.15885312260642864,"corpus_percentile":64.19896340991723,"corpus_rank":4629,"citation_count":12,"citer_count":10,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.6833,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":649694,"name":"Ivan Barilar","orcid":"0000-0002-4789-2777","position":1,"is_corresponding":false},{"id":1001313,"name":"Leonardo Silva de Araujo","orcid":"0000-0002-4415-826X","position":2,"is_corresponding":false},{"id":317562,"name":"Anne W. Rimoin","orcid":"0000-0002-0662-9067","position":3,"is_corresponding":false},{"id":642318,"name":"Daniel M. Parker","orcid":"0000-0002-5352-7338","position":4,"is_corresponding":false},{"id":417007,"name":"Rosanna Boyd","orcid":null,"position":5,"is_corresponding":false},{"id":415903,"name":"James L. Tobias","orcid":"0000-0001-8694-5002","position":6,"is_corresponding":false},{"id":371437,"name":"Patrick K. Moonan","orcid":"0000-0002-3550-2065","position":7,"is_corresponding":false},{"id":370201,"name":"Eleanor S. Click","orcid":null,"position":8,"is_corresponding":false},{"id":415904,"name":"Alyssa Finlay","orcid":"0000-0002-7597-2395","position":9,"is_corresponding":false},{"id":415905,"name":"John E. Oeltmann","orcid":"0000-0002-9728-8746","position":10,"is_corresponding":false},{"id":329445,"name":"Vladimir N. Minin","orcid":"0000-0002-1917-9288","position":11,"is_corresponding":false},{"id":417012,"name":"Chawangwa Modongo","orcid":null,"position":12,"is_corresponding":false},{"id":387855,"name":"Nicola M. Zetola","orcid":"0000-0003-0712-8579","position":13,"is_corresponding":false},{"id":96123,"name":"Stefan Niemann","orcid":"0000-0002-6604-0684","position":14,"is_corresponding":false},{"id":414372,"name":"Sanghyuk S. Shin","orcid":"0000-0001-9982-4373","position":15,"is_corresponding":false},{"id":1001312,"name":"Chelsea R. Baker","orcid":"0000-0001-5501-677X","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T01:11:44.152490Z","pmid":"37081530","pmcid":"PMC10124643","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}