{"doi":"10.3201/eid2712.211150","title":"Novel Assay to Measure Seroprevalence of Zika Virus in the Philippines","abstract":"Zika virus (ZIKV) is a member of the Flaviviridae family, which includes other clinically notable viruses such as the 4 dengue virus serotypes (DENV-1-4). Distinguishing DENVs from ZIKV using the established serologic assays widely used for monitoring DENV transmission is difficult because of antibody cross-reactivity between these closely related flaviviruses. We describe a modified and improved recombinant envelope domain III-based serologic assay for detecting ZIKV type-specific antibodies in regions with endemic DENV transmission. When the assay was used to measure ZIKV seroprevalence in 2017 among children 9-14 years of age living in a region of the Philippines with endemic DENV transmission, we observed a ZIKV seroprevalence of 18%. Investigators should consider using the ZIKV envelope domain III-based assay, which is simple and readily adaptable for use in standard clinical and public health laboratories, to assess ZIKV seroprevalence in areas with endemic DENV transmission.","journal":"Emerging infectious diseases","year":2021,"id":194400,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9589,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":103774,"name":"Ramesh Jadi","orcid":"0000-0002-5710-4893","position":1,"is_corresponding":false},{"id":236666,"name":"Bruno Segovia-Chumbez","orcid":"0000-0002-7730-9386","position":2,"is_corresponding":false},{"id":764914,"name":"Jedas Veronica Daag","orcid":null,"position":3,"is_corresponding":false},{"id":764225,"name":"Michelle Ylade","orcid":"0000-0002-2653-4460","position":4,"is_corresponding":false},{"id":764226,"name":"Freddy A. Medina","orcid":"0000-0003-1320-593X","position":5,"is_corresponding":false},{"id":306892,"name":"Tyler M. Sharp","orcid":"0000-0002-7131-8257","position":6,"is_corresponding":false},{"id":306899,"name":"Jorge L. Muñoz‐Jordán","orcid":"0000-0002-1596-8343","position":7,"is_corresponding":false},{"id":364848,"name":"In‐Kyu Yoon","orcid":"0009-0003-2512-6873","position":8,"is_corresponding":false},{"id":764227,"name":"Jacqueline Deen","orcid":"0000-0001-8875-5026","position":9,"is_corresponding":false},{"id":744758,"name":"Anna Lena Lopez","orcid":"0000-0003-0013-620X","position":10,"is_corresponding":false},{"id":103776,"name":"Aravinda M. de Silva","orcid":null,"position":11,"is_corresponding":false},{"id":103773,"name":"Lakshmanane Premkumar","orcid":"0000-0002-1736-1350","position":12,"is_corresponding":false},{"id":666953,"name":"Cameron Adams","orcid":"0000-0001-7998-0141","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-18T23:49:59.476757Z","pmid":"34808091","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}