{"doi":"10.3181/00379727-124-31968","title":"Effects of Loading with Tryptophan Metabolites on Metabolism of DL-Tryptophan-7a-C11 in Rats.","abstract":null,"journal":"Experimental Biology and Medicine","year":1967,"id":600882,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":538499,"name":"R. R. Brown","orcid":null,"position":1,"is_corresponding":false},{"id":1540577,"name":"M. Schmaeler","orcid":null,"position":2,"is_corresponding":false},{"id":1540572,"name":"L. Y. Hankes","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Effects of Loading with Tryptophan Metabolites on Metabolism of DL-Tryptophan-7a-C11 in Rats.","abstract":"SummaryDL-tryptophan-7a-C14 was administered intraperitoneally to adult rats at a level of 0.715 mg/kg of body weight. In some experiments loads of L-tryptophan, kynu-renine, hydroxyanthranilic acid or quinolinic acid (equivalent on a molar basis to 2 g of L-tryptophan in a 70 kg man) were given 30 minutes prior to the labeled tryptophan. Rats given a tracer dose of DL-tryptophan-7a-C14 excreted 18-20% of the C14 as C14O2 and 7.2-7.6% in the urine in the first 12 hours. The injection of a load of L-tryptophan 30 minutes prior to the DL-tryptophan- 7a-C14 caused an increase in C14O2 to 33.6% of the dose and the urinary C14 level increased to 9.1%. The injection of 0.14 mM/kg of 3-hydroxyanthra-nilic acid 30 minutes prior to administration of the labeled tryptophan caused a depression of the C14O2 excretion to 8.8% and increased the urinary C14 level to 23.6%. Autoradio-graphs of chromatograms of the urines and C14 analyses of more than 8 of the known tryptophan metabolites isolated from the urines showed t...","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"6024837","pmcid":null,"openalex_id":"https://openalex.org/W1964128476","authors":[],"funders":[],"total_grants":0,"fwci":0.6083,"citation_percentile":0.65217391,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://doi.org/10.3181/00379727-124-31968","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/6024837","host_type":"repository"}],"fields_of_study":["Tryptophan and brain disorders","Neurotransmitter Receptor Influence on Behavior","Biochemical Acid Research Studies"],"mesh_terms":["Animals","Autoradiography","Carbon Dioxide","Carbon Isotopes","Chromatography, Paper","Kynurenine","Pyridines","Tryptophan","Rats","ortho-Aminobenzoates"],"keywords":["Tryptophan","Tryptophan Metabolism","Metabolism","Chemistry","Biochemistry","Pharmacology","Biology","Amino acid"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T14:24:54.651896Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}