{"doi":"10.3177/jnsv.51.426","title":"Expression of Calbindin-D9k, VDR and Cdx-2 Messenger RNA in the Process by Which Fructooligosaccharides Increase Calcium Absorption in Rats","abstract":null,"journal":"Journal of Nutritional Science and Vitaminology","year":2005,"id":683706,"datarank":0.44166584687496613,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.0,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1786101,"name":"Atsutane OHTA","orcid":null,"position":1,"is_corresponding":false},{"id":1786102,"name":"Kensuke SAKAI","orcid":null,"position":2,"is_corresponding":false},{"id":1786103,"name":"Keiko SAKUMA","orcid":null,"position":3,"is_corresponding":false},{"id":1786100,"name":"Akiko FUKUSHIMA","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Expression of Calbindin-D9k, VDR and Cdx-2 Messenger RNA in the Process by Which Fructooligosaccharides Increase Calcium Absorption in Rats","abstract":"We have previously shown, through evidence that the expression of calbindin-D9k protein shows a dose-dependent change in the intestine, that calbindin-D9k plays a role in the ability of a fructooligosaccharide (FOS) diet to increase calcium absorption. This study shows that the regulation of calbindin-D9k expression occurs at the transcriptional level in a segment-specific manner, decreasing in the proximal intestine and increasing in the colorectal segment. To determine the transcriptional regulation of the FOS diet on calbindin-D9k expression, two transcription factors, vitamin D receptor (VDR) and cdx-2, were analyzed during 10 d feeding of the FOS diet. The mRNA expression of VDR and cdx-2 was influenced by the FOS diet and showed a segment-specific change. In the proximal small intestine, there was a significant correlation between the changes in both mRNAs (r = 0.69, p < 0.01), while the expression of calbindin-D9k correlated neither with VDR nor with cdx-2. This means that the transcriptional change induced by the FOS diet was not regulated by VDR and cdx-2. In the colorectal segment, there were significant correlations between gene expressions of calbindin-D9k vs. VDR, r = 0.73, p < 0.01 and calbindin-D9k vs. cdx-2, r = 0.52, p < 0.05. These results suggested that both transcription factors, VDR and cdx-2, were involved in the regulation of calbindin-D9k gene expression in the colorectal segment during the process through which the FOS diet enhanced calcium absorption.","is_dataset_classified":null,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16521702","pmcid":null,"openalex_id":"https://openalex.org/W2026970507","authors":[],"funders":[],"total_grants":0,"fwci":0.6575,"citation_percentile":0.69296793,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":2},{"year":2016,"count":2},{"year":2017,"count":2},{"year":2020,"count":2},{"year":2022,"count":1},{"year":2026,"count":1}],"oa_status":"gold","license":null,"oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/jnsv1973/51/6/51_6_426/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/jnsv1973/51/6/51_6_426/_pdf","host_type":"publisher"},{"url":"https://doi.org/10.3177/jnsv.51.426","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16521702","host_type":"repository"}],"fields_of_study":["Microbial Metabolites in Food Biotechnology","Helicobacter pylori-related gastroenterology studies","Digestive system and related health"],"mesh_terms":["CDX2 Transcription Factor","Animals","Calcium","Diet","DNA","Gene Expression Regulation","Intestinal Absorption","Intestinal Mucosa","Male","Oligosaccharides","Organ Size","RNA, Messenger","Blotting, Northern","Trans-Activators","Rats, Sprague-Dawley","Receptors, Calcitriol","Homeodomain Proteins","Rats","Calbindins","S100 Calcium Binding Protein G"],"keywords":["Calcitriol receptor","Calbindin","TRPV6","Biology","Internal medicine","Endocrinology","Calcium","Vitamin D-dependent calcium-binding protein","Gene expression","Calcium metabolism","Messenger RNA","Vitamin D and neurology","Gene","Biochemistry","Medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T11:56:39.751704Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}