{"doi":"10.3174/ajnr.a7901","title":"Cost-Effectiveness Analysis of<sup>68</sup>Ga-DOTATATE PET/MRI in Radiotherapy Planning in Patients with Intermediate-Risk Meningioma","abstract":"<h3>BACKGROUND AND PURPOSE:</h3> While contrast-enhanced MR imaging is the criterion standard in meningioma diagnosis and treatment response assessment, gallium <sup>68</sup>Ga-DOTATATE PET/MR imaging has increasingly demonstrated utility in meningioma diagnosis and management. Integrating <sup>68</sup>Ga-DOTATATE PET/MR imaging in postsurgical radiation planning reduces the planning target volume and organ-at-risk dose. However, <sup>68</sup>Ga-DOTATATE PET/MR imaging is not widely implemented in clinical practice due to higher perceived costs. Our study analyzes the cost-effectiveness of <sup>68</sup>Ga-DOTATATE PET/MR imaging for postresection radiation therapy planning in patients with intermediate-risk meningioma. <h3>MATERIALS AND METHODS:</h3> We developed a decision-analytical model based on both recommended guidelines on meningioma management and our institutional experience. Markov models were implemented to estimate quality-adjusted life-years (QALY). Cost-effectiveness analyses with willingness-to-pay thresholds of $50,000/QALY and $100,000/QALY were performed from a societal perspective. Sensitivity analyses were conducted to validate the results. Model input values were based on published literature. <h3>RESULTS:</h3> The cost-effectiveness results demonstrated that <sup>68</sup>Ga-DOTATATE PET/MR imaging yields higher QALY (5.47 versus 5.05) at a higher cost ($404,260 versus $395,535) compared with MR imaging alone. The incremental cost-effectiveness ratio analysis determined that <sup>68</sup>Ga-DOTATATE PET/MR imaging is cost-effective at a willingness to pay of $50,000/QALY and $100,000/QALY. Furthermore, sensitivity analyses showed that <sup>68</sup>Ga-DOTATATE PET/MR imaging is cost-effective at $50,000/QALY ($100,000/QALY) for specificity and sensitivity values above 76% (58%) and 53% (44%), respectively. <h3>CONCLUSIONS:</h3> <sup>68</sup>Ga-DOTATATE PET/MR imaging as an adjunct imaging technique is cost-effective in postoperative treatment planning in patients with meningiomas. Most important, the model results show that the sensitivity and specificity cost-effective thresholds of <sup>68</sup>Ga-DOTATATE PET/MR imaging could be attained in clinical practice.","journal":"American Journal of Neuroradiology","year":2023,"id":338472,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":461632,"name":"Gabriela Martinez","orcid":"0000-0003-4919-0733","position":1,"is_corresponding":false},{"id":528735,"name":"Sean S. Mahase","orcid":"0000-0003-3488-6981","position":2,"is_corresponding":false},{"id":964332,"name":"Michelle Roytman","orcid":"0000-0001-5739-1274","position":3,"is_corresponding":false},{"id":381108,"name":"Arsalan Haghdel","orcid":"0000-0002-6744-9625","position":4,"is_corresponding":false},{"id":11539,"name":"Sean Kim","orcid":"0000-0001-5415-5911","position":5,"is_corresponding":false},{"id":728121,"name":"Gabriela Madera","orcid":null,"position":6,"is_corresponding":false},{"id":1070949,"name":"Rajiv Magge","orcid":"0000-0002-2870-6895","position":7,"is_corresponding":false},{"id":353980,"name":"Peter Pan","orcid":"0000-0001-8833-0757","position":8,"is_corresponding":false},{"id":251174,"name":"Rohan Ramakrishna","orcid":"0000-0002-1166-6073","position":9,"is_corresponding":false},{"id":227192,"name":"Theodore H. Schwartz","orcid":"0000-0003-4464-7394","position":10,"is_corresponding":false},{"id":752095,"name":"Susan C. Pannullo","orcid":"0000-0001-6947-1837","position":11,"is_corresponding":false},{"id":354018,"name":"Joseph R. Osborne","orcid":"0000-0003-0232-5960","position":12,"is_corresponding":false},{"id":278955,"name":"Eaton Lin","orcid":"0000-0003-1860-4059","position":13,"is_corresponding":false},{"id":553574,"name":"Jonathan Knisely","orcid":"0000-0001-5975-8199","position":14,"is_corresponding":false},{"id":461636,"name":"Pina C. Sanelli","orcid":"0000-0002-9633-3699","position":15,"is_corresponding":false},{"id":367140,"name":"Jana Ivanidze","orcid":"0000-0002-6470-5400","position":16,"is_corresponding":false},{"id":1070948,"name":"José A. Rodriguez","orcid":"0000-0002-6303-1133","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T01:10:35.973121Z","pmid":"37290818","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}