{"doi":"10.3174/ajnr.a6937","title":"Pilot Study of Hyperpolarized <sup>13</sup>C Metabolic Imaging in Pediatric Patients with Diffuse Intrinsic Pontine Glioma and Other CNS Cancers","abstract":"BACKGROUND AND PURPOSE: Pediatric CNS tumors commonly present challenges for radiographic interpretation on conventional MR imaging. This study sought to investigate the safety and tolerability of hyperpolarized carbon-13 (HP-13 C) metabolic imaging in pediatric patients with brain tumors. MATERIALS AND METHODS: Pediatric patients 3 to 18 years of age who were previously diagnosed with a brain tumor and could undergo MR imaging without sedation were eligible to enroll in this safety study of HP [1-13 C]pyruvate. Participants received a onetime injection of HP [1-13 C]pyruvate and were imaged using dynamic HP-13 C MR imaging. We assessed 2 dose levels: 0.34 mL/kg and the highest tolerated adult dose of 0.43 mL/kg. Participants were monitored throughout imaging and for 60 minutes postinjection, including pre-and postinjection electrocardiograms and vital sign measurements.","journal":"American Journal of Neuroradiology","year":2020,"id":101153,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9134,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":495580,"name":"Ilwoo Park","orcid":"0000-0001-6022-8363","position":1,"is_corresponding":false},{"id":32668,"name":"Cassie Kline","orcid":"0000-0001-7765-7690","position":2,"is_corresponding":false},{"id":460831,"name":"Hsin‐Yu Chen","orcid":"0000-0002-2765-1685","position":3,"is_corresponding":false},{"id":345502,"name":"Jeremy W. Gordon","orcid":"0000-0003-2760-4886","position":4,"is_corresponding":false},{"id":495581,"name":"Shannon Raber","orcid":"0000-0002-0297-0559","position":5,"is_corresponding":false},{"id":495582,"name":"Carly Hoffman","orcid":"0000-0003-0831-4285","position":6,"is_corresponding":false},{"id":495583,"name":"Yaewon Kim","orcid":"0000-0003-1016-1572","position":7,"is_corresponding":false},{"id":495584,"name":"Kosuke Okamoto","orcid":"0000-0001-7966-8844","position":8,"is_corresponding":false},{"id":345507,"name":"Daniel B. Vigneron","orcid":"0000-0001-5795-8699","position":9,"is_corresponding":false},{"id":345506,"name":"Janine Lupo","orcid":"0000-0002-0051-6387","position":10,"is_corresponding":false},{"id":32675,"name":"Michael D. Prados","orcid":"0000-0002-9630-2075","position":11,"is_corresponding":false},{"id":345508,"name":"Yan Li","orcid":"0000-0003-2145-2869","position":12,"is_corresponding":false},{"id":334412,"name":"Duan Xu","orcid":"0000-0003-0550-4235","position":13,"is_corresponding":false},{"id":32673,"name":"Sabine Mueller","orcid":"0000-0002-3452-5150","position":14,"is_corresponding":false},{"id":345501,"name":"Adam Autry","orcid":"0000-0002-7062-4965","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-18T22:39:38.259162Z","pmid":"33272950","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}