{"doi":"10.3174/ajnr.a6869","title":"Tractography of the Cerebellar Peduncles in Second- and Third-Trimester Fetuses","abstract":"BACKGROUND AND PURPOSE: Little is known about microstructural development of cerebellar white matter in vivo. This study aimed to investigate developmental changes of the cerebellar peduncles in second- and third-trimester healthy fetuses using motion-corrected DTI and tractography. MATERIALS AND METHODS: 3T data of 81 healthy fetuses were reviewed. Structural imaging consisted of multiplanar T2-single-shot sequences; DTI consisted of a series of 12-direction diffusion. A robust motion-tracked section-to-volume registration algorithm reconstructed images. ROI-based deterministic tractography was performed using anatomic landmarks described in postnatal tractography. Asymmetry was evaluated qualitatively with a perceived difference of >25% between sides. Linear regression evaluated gestational age as a predictor of tract volume, ADC, and fractional anisotropy. RESULTS: < .001) than the superior cerebellar peduncle after controlling for gestational age. CONCLUSIONS: A robust motion-tracked section-to-volume registration algorithm enabled deterministic tractography of the superior cerebellar peduncle and middle cerebellar peduncle in vivo and allowed characterization of developmental changes.","journal":"American Journal of Neuroradiology","year":2021,"id":199681,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8964,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":345434,"name":"Onur Afacan","orcid":"0000-0003-2112-3205","position":1,"is_corresponding":false},{"id":345435,"name":"Shadab Khan","orcid":"0000-0002-0754-8912","position":2,"is_corresponding":false},{"id":345436,"name":"Bahram Marami","orcid":"0000-0003-2555-2402","position":3,"is_corresponding":false},{"id":302561,"name":"Caitlin K. Rollins","orcid":"0000-0002-0500-0056","position":4,"is_corresponding":false},{"id":277675,"name":"Cynthia M. Ortinau","orcid":"0000-0003-0851-0796","position":5,"is_corresponding":false},{"id":302563,"name":"Clemente Velasco‐Annis","orcid":"0000-0002-7176-3852","position":6,"is_corresponding":false},{"id":291219,"name":"Simon K. Warfield","orcid":"0000-0002-7659-3880","position":7,"is_corresponding":false},{"id":302565,"name":"Ali Gholipour","orcid":"0000-0001-7699-4564","position":8,"is_corresponding":false},{"id":93752,"name":"Camilo Jaimes","orcid":"0000-0002-7169-4244","position":9,"is_corresponding":false},{"id":345433,"name":"Fedel Machado‐Rivas","orcid":"0000-0003-3095-414X","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-18T23:50:40.558460Z","pmid":"33431505","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}