{"doi":"10.3174/ajnr.a6703","title":"Evaluation of Ultrafast Wave-CAIPI MPRAGE for Visual Grading and Automated Measurement of Brain Tissue Volume","abstract":"<h3>BACKGROUND AND PURPOSE:</h3> Volumetric brain MR imaging typically has long acquisition times. We sought to evaluate an ultrafast MPRAGE sequence based on Wave-CAIPI (Wave-MPRAGE) compared with standard MPRAGE for evaluation of regional brain tissue volumes. <h3>MATERIALS AND METHODS:</h3> We performed scan-rescan experiments in 10 healthy volunteers to evaluate the intraindividual variability of the brain volumes measured using the standard and Wave-MPRAGE sequences. We then evaluated 43 consecutive patients undergoing brain MR imaging. Patients underwent 3T brain MR imaging, including a standard MPRAGE sequence (acceleration factor [<i>R</i>] = 2, acquisition time [TA] = 5.2 minutes) and an ultrafast Wave-MPRAGE sequence (<i>R</i> = 9, TA = 1.15 minutes for the 32-channel coil; <i>R</i> = 6, TA = 1.75 minutes for the 20-channel coil). Automated segmentation of regional brain volume was performed. Two radiologists evaluated regional brain atrophy using semiquantitative visual rating scales. <h3>RESULTS:</h3> The mean absolute symmetrized percent change in the healthy volunteers participating in the scan-rescan experiments was not statistically different in any brain region for both the standard and Wave-MPRAGE sequences. In the patients undergoing evaluation for neurodegenerative disease, the Dice coefficient of similarity between volumetric measurements obtained from standard and Wave-MPRAGE ranged from 0.86 to 0.95. Similarly, for all regions, the absolute symmetrized percent change for brain volume and cortical thickness showed &lt;6% difference between the 2 sequences. In the semiquantitative visual comparison, the differences between the 2 radiologists’ scores were not clinically or statistically significant. <h3>CONCLUSIONS:</h3> Brain volumes estimated using ultrafast Wave-MPRAGE show low intraindividual variability and are comparable with those estimated using standard MPRAGE in patients undergoing clinical evaluation for suspected neurodegenerative disease.","journal":"American Journal of Neuroradiology","year":2020,"id":93825,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":39,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9296,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":364087,"name":"John Conklin","orcid":"0000-0001-9921-2086","position":1,"is_corresponding":false},{"id":241412,"name":"Stephen Cauley","orcid":"0000-0002-6147-6016","position":2,"is_corresponding":false},{"id":263269,"name":"Kawin Setsompop","orcid":"0000-0003-0455-7634","position":3,"is_corresponding":false},{"id":251970,"name":"Qiyuan Tian","orcid":"0000-0002-8350-5295","position":4,"is_corresponding":false},{"id":344032,"name":"Daniel Polak","orcid":"0000-0001-9781-1528","position":5,"is_corresponding":false},{"id":245952,"name":"Maya N. Polackal","orcid":"0000-0001-9236-5039","position":6,"is_corresponding":false},{"id":365477,"name":"Daniel Nicolas Splitthoff","orcid":null,"position":7,"is_corresponding":false},{"id":468030,"name":"W. Liu","orcid":"0000-0002-8072-7116","position":8,"is_corresponding":false},{"id":367512,"name":"R. Gilberto González","orcid":"0000-0002-0234-3897","position":9,"is_corresponding":false},{"id":307822,"name":"Pamela W. Schaefer","orcid":"0000-0002-4222-6134","position":10,"is_corresponding":false},{"id":307821,"name":"John E. Kirsch","orcid":"0000-0002-0389-9475","position":11,"is_corresponding":false},{"id":226557,"name":"Otto Rapalino","orcid":"0000-0002-5038-4183","position":12,"is_corresponding":false},{"id":263270,"name":"Susie Y. Huang","orcid":"0000-0003-2950-7254","position":13,"is_corresponding":false},{"id":364088,"name":"Maria Gabriela Figueiró Longo","orcid":"0000-0001-6819-4890","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-18T22:31:34.149524Z","pmid":"32732274","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}