{"doi":"10.31438/trf.hh2022.34","title":"POLYMER AND STAINLESS STEEL-BASED 3D MICROELECTRODE ARRAYS (3D MEAS), WITH PENTA-MODAL SENSING CAPABILITIES FOR THE INVESTIGATION OF ELECTROGNIC CELLS","abstract":"Benchtop tissue cultures have historically provided major breakthroughs in biological research.Modern \"on-a-chip\" and Microphysiological Systems (MPS) demand integrated sensing/stimulation modalities, to produce complex, multiplexed datasets.To this end, novel fabrication strategies incorporating readily available materials, including polymers and steel alloys, are exciting avenues for the development of such multifunctional biosensors.Here, we showcase a Penta-Modal biosensor platform, which incorporates a transparent polymer substrate (for cellular image analysis), stainless steel (SS) 3D microelectrode array (3D MEA) structures, with an included 3D microfluidic adaptation, and both temperature and analyte sensing capabilities all on a single chip.Together, this device demonstrates the potential for a highly versatile data collection regimen, in a compact one-chip platform.","journal":null,"year":2022,"id":302412,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9523,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":994773,"name":"Julia Freitas","orcid":null,"position":1,"is_corresponding":false},{"id":994774,"name":"Omar Cepeda-Torres","orcid":null,"position":2,"is_corresponding":false},{"id":994423,"name":"Aliyah Baksh","orcid":"0000-0002-6980-4432","position":3,"is_corresponding":false},{"id":994775,"name":"Jorge Velasco Manrique","orcid":null,"position":4,"is_corresponding":false},{"id":270509,"name":"Swaminathan Rajaraman","orcid":"0000-0003-2279-2013","position":5,"is_corresponding":false},{"id":443566,"name":"Charles M. Didier","orcid":"0000-0002-5556-8694","position":0,"is_corresponding":true}],"reference_count":11,"raw_metadata":null,"created_at":"2026-07-19T00:32:16.279991Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}