{"doi":"10.3126/ajms.v13i10.45513","title":"Use of Cyclosporine A and danazol in treatment of aplastic anemia: A real-world data from a teaching hospital in South India","abstract":"<jats:p>Background: Due to financial constraints, there are limited treatment options for Aplastic anemia (AA) in developing countries.\nAims and Objectives: In the present observational retrospective study, utility of Cyclosporine A (CsA) along with Danazol (an anabolic steroid) in AA was assessed.\nMaterials and Methods: The study included patients of AA treated in our hospital from 2017 to 2020.\n Results: The present study included total of 95 patients. Out of these, 69 patients (73%) were lost to follow-up. It was observed that, out of 26 patients who could be followed up, 18 (69%) patients responded to the treatment (transfusion independent) at the end of 6 months. Out of 18 patients who had responded, two were very severe AA, 12 were severe AA, and four were non-severe AA patients. Eleven out of 18 (61.1%) females responded, whereas seven out of eight males (87.5%) responded to the treatment. In four patients who received Eltrombopag in addition to CsA-Danazol, three patients responded to the therapy.\nConclusion: Treatment with CsA and Danazol may represent a promising therapy for patients with AA, especially in resource limited settings. Further, large-scale collaborative studies are necessary to evaluate such approaches in management of AA.</jats:p>","journal":"Asian Journal of Medical Sciences","year":2022,"id":618169,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1594540,"name":"Renukaradhya K Math","orcid":null,"position":1,"is_corresponding":false},{"id":1594541,"name":"Deepak Goni","orcid":"0000-0003-4452-6904","position":2,"is_corresponding":false},{"id":1594542,"name":"Girish Balikai","orcid":"0000-0003-0325-4260","position":3,"is_corresponding":false},{"id":1594543,"name":"Ambuja Savanur","orcid":"0000-0002-1474-4380","position":4,"is_corresponding":false},{"id":1594544,"name":"Nayana Mudennavar","orcid":"0000-0001-5264-6493","position":5,"is_corresponding":false},{"id":1594545,"name":"Palaksha Kanive Javaregowda","orcid":null,"position":6,"is_corresponding":false},{"id":1594539,"name":"Girish Kamat","orcid":"0000-0002-9144-2001","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Use of Cyclosporine A and danazol in treatment of aplastic anemia: A real-world data from a teaching hospital in South India","abstract":"<jats:p>Background: Due to financial constraints, there are limited treatment options for Aplastic anemia (AA) in developing countries.\nAims and Objectives: In the present observational retrospective study, utility of Cyclosporine A (CsA) along with Danazol (an anabolic steroid) in AA was assessed.\nMaterials and Methods: The study included patients of AA treated in our hospital from 2017 to 2020.\n Results: The present study included total of 95 patients. Out of these, 69 patients (73%) were lost to follow-up. It was observed that, out of 26 patients who could be followed up, 18 (69%) patients responded to the treatment (transfusion independent) at the end of 6 months. Out of 18 patients who had responded, two were very severe AA, 12 were severe AA, and four were non-severe AA patients. Eleven out of 18 (61.1%) females responded, whereas seven out of eight males (87.5%) responded to the treatment. In four patients who received Eltrombopag in addition to CsA-Danazol, three patients responded to the therapy.\nConclusion: Treatment with CsA and Danazol may represent a promising therapy for patients with AA, especially in resource limited settings. Further, large-scale collaborative studies are necessary to evaluate such approaches in management of AA.</jats:p>","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19910364","pmcid":null,"openalex_id":"https://openalex.org/W4298395983","authors":[],"funders":[],"total_grants":0,"fwci":0.6314,"citation_percentile":0.70655123,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":2},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://www.nepjol.info/index.php/AJMS/article/download/45513/36219","host_type":"journal"},{"url":"https://www.nepjol.info/index.php/AJMS/article/download/45513/36219","host_type":"publisher"},{"url":"https://doi.org/10.3126/ajms.v13i10.45513","host_type":"journal"},{"url":"https://doaj.org/article/1a80a4482f4f4ef783b61497b9f9c84f","host_type":"repository"}],"fields_of_study":["Hematopoietic Stem Cell Transplantation","Mesenchymal stem cell research"],"mesh_terms":[],"keywords":["Medicine","Danazol","Aplastic anemia","Retrospective cohort study","Observational study","Internal medicine","Anabolic steroid","Anemia","Surgery","Pediatrics","Anabolism","Bone marrow"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Partnerships for the goals"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T03:38:51.875719Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}