{"doi":"10.31235/osf.io/gru6e","title":"Cohort Profile: The Adverse Childhood Experiences (ACE) Cohort of the Malawi Longitudinal Study of Families and Health (MLSFH)","abstract":"Purpose: The Adverse Childhood Experiences cohort of the Malawi Longitudinal Study of Fami-lies and Health (MLSFH-ACE) is a study of adolescents created during 2017-21. It provides un-paralleled opportunity to examine the longitudinal impact of adverse childhood experiences on health and development across the early life course. The MLSFH-ACE cohort provides rich data on adolescents, their children, and adult caregivers in a low-income, high HIV prevalence context in sub-Saharan African (SSA).Participants: The MLSFH-ACE cohort is a population-based cohort of adolescents living in three districts in rural Malawi. Wave 1 enrollment took place in 2017-2018 and included 2061 adoles-cents aged 10-16 years and 1438 caregivers. Wave 2 took place in 2021 and included data on 1878 adolescents and 208 offspring. Survey instruments captured ACEs during childhood and adolescence, HIV-related behavioral risk, mental and physical health, cognitive development and education, intimate partner violence (IPV), marriage and aspirations, early transitions to adult-hood, and protective factors. Biological indicators included HIV, HSV2, and anthropometric measurements.Findings to date: Key findings include a high prevalence of ACEs among adolescence in Mala-wi, a low incidence of HIV, and positive associations between ACEs scores and composite HIV risk scores. There were also strong associations between ACEs and both IPV victimization and perpetration.Future plans: MLSFH-ACE data will be publicly released and will provide a wealth of information on ACEs and adolescent outcomes in low-income, HIV-endemic SSA context. Future expansions of the cohort are planned to capture data during early adulthood.","journal":"SocArXiv (OSF Preprints)","year":2023,"id":410562,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":0.0,"corpus_rank":10062,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.9472,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":455593,"name":"James Mwera","orcid":null,"position":1,"is_corresponding":false},{"id":1190516,"name":"Rui Yang","orcid":"0000-0001-7167-297X","position":2,"is_corresponding":false},{"id":875513,"name":"Etienne Breton","orcid":null,"position":3,"is_corresponding":false},{"id":1129980,"name":"Andrew Zulu","orcid":"0000-0001-6698-2025","position":4,"is_corresponding":false},{"id":288111,"name":"Jere R. Behrman","orcid":"0000-0001-7835-6283","position":5,"is_corresponding":false},{"id":255245,"name":"Hans‐Peter Kohler","orcid":"0000-0003-0639-4349","position":6,"is_corresponding":false},{"id":353734,"name":"Rachel Kidman","orcid":"0000-0001-7202-5571","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T01:21:35.071397Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}