{"doi":"10.31235/osf.io/gcuhn","title":"Research-targeting, spillovers, and the direction of science: Evidence from HIV research-funding","abstract":"HIV/AIDS has been a major focus for research funders. The US National Institutes of Health (NIH) alone has spent over $70bn on HIV/AIDS. Such investments ushered in antiviral drugs, helping to reverse a rapidly growing HIV/AIDS pandemic. However, the idea that research can deliver unexpected benefits beyond its targeted field, in fact, predates HIV/AIDS to at least Vannevar Bush’s influential 1945 report. Cross-disease spillovers – research investments that yield benefits beyond the target disease – remains unexplored, even though it could inform both priority-setting and calculations of returns on research investments. To this end, we took a sample of NIH’s HIV grants and examined their publications. We analyzed 118,493 publications and found that 62% of these were spillovers. We used Medical Subject Headings (MeSH) terms assigned to publications to explore the content of these spillovers, as well as to corroborate non-spillovers. We located spillovers on a network of MeSH co-occurrence, drawn from the broader universe of biomedical publications, for comparison. We found that HIV spillovers were unevenly distributed across disease-space, and often in close proximity to HIV (60% local; 40% remote). We further reviewed 1,000 grant–publication pairs from a local sample and 1,000 pairs from a remote sample. For local spillovers, a quarter seemed to be unexpected, on the basis of their grant description; for remote spillovers, that proportion increased to one third. We also found that the NIH funding institutes whose remits were most closely related to HIV/AIDS were less likely to produce spillovers than others. We discuss implications for theory and policy.","journal":"UCL Discovery (University College London)","year":2023,"id":398848,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9475,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1175034,"name":"Josie Coburn","orcid":"0000-0002-1665-1946","position":1,"is_corresponding":false},{"id":949974,"name":"Duncan A.Q. Moore","orcid":"0000-0002-8705-2932","position":2,"is_corresponding":false},{"id":949973,"name":"Ohid Yaqub","orcid":"0000-0001-9913-417X","position":0,"is_corresponding":true}],"reference_count":100,"raw_metadata":null,"created_at":"2026-07-19T01:19:51.724387Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}