{"doi":"10.31234/osf.io/z9w3t","title":"The Central Extended Amygdala Guides Survival-Relevant Tradeoffs for Action Selection","abstract":"To thrive in challenging environments, individuals must pursue rewards while avoiding threats. Aberrant threat response is characteristic of anxiety disorders. Extensive studies in animals and humans have identified the central extended amygdala (EAc)—which includes the central nucleus of the amygdala (Ce) and the bed nucleus of the stria terminalis (BST)—as a conserved substrate for defensive behavior. These studies suggest the EAc influences defensive responding and assembles fearful and anxious states. One impact of these investigations has been the proliferation of a view that the EAc is fundamentally a defensive substrate. Recently, however, rodent studies have implicated the EAc in numerous appetitive and consummatory processes, yielding fresh insights into the microcircuitry of emotion-relevant response selection across various contexts. Coupled with the EAc’s centrality in a conserved network of brain regions that encode multisensory environmental and interoceptive information, these findings allude to a broader role for the EAc as an arbiter of survival-relevant tradeoffs for action selection. Understanding how the EAc optimizes these tradeoffs holds great promise in elucidating anxiety-related psychopathology.","journal":"PsyArXiv (OSF Preprints)","year":2022,"id":303528,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9532,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":268757,"name":"Andrew S. Fox","orcid":"0000-0003-0695-3323","position":1,"is_corresponding":false},{"id":449009,"name":"Daniel C. Holley","orcid":"0000-0002-3322-8541","position":0,"is_corresponding":true}],"reference_count":90,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:32:24.307938Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}