{"doi":"10.31234/osf.io/xp5db","title":"Hippocampal Threat Reactivity Interacts with Physiological Arousal to Predict PTSD Symptoms","abstract":"Prior studies highlight how threat-related arousal may impair hippocampal function. Hippocampal impairments are reliably associated with post-traumatic stress disorder (PTSD); however, little research has characterized how increased threat-sensitivity may drive arousal responses to alter hippocampal reactivity, and further how these alterations relate to the sequelae of trauma-related symptoms. In a sample of individuals recently exposed to trauma (N=117, 76 Female), we found that PTSD symptoms at 2-weeks and 3-months were associated with decreased hippocampal responses to threat as assessed with functional magnetic resonance imaging (fMRI). Further, decreased hippocampal threat sensitivity was predicted by individual differences in fear-potentiated startle, an arousal-mediated behavior. Critically, the relationship between hippocampal threat sensitivity and PTSD symptomology only emerged in individuals who showed high threat-related arousal. Collectively, our finding suggests that development of PTSD is associated with threat-related decreases in hippocampal function, due to increases in fear-potentiated arousal.","journal":"PsyArXiv (OSF Preprints)","year":2021,"id":218763,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":741119,"name":"David F. 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