{"doi":"10.31234/osf.io/ujebq_v2","title":"ATN blood biomarkers are related to digital cognitive assessment in type 1 diabetes","abstract":"Published Version: This article has been peer-reviewed and published in Alzheimer’s & Dementia. Please cite the published version:Fonseca LM, Beeri MS, Hawks ZW, Jung L, Cleveland M, Delgado N, Bulger J, Grinspoon E, Janess K, Sliwinski MJ, Weinstock RS, Chhatwal JP, Kivisäkk P, Germine LT, Chaytor NS. ATN blood biomarkers are related to digital cognitive assessment in type 1 diabetes. Alzheimers Dement (Amst). 2024 Oct 23;16(4):e70029. doi: 10.1002/dad2.70029. PMID: 39445343; PMCID: PMC11497176.https://doi.org/10.1002/dad2.70029INTRODUCTION, Associations between Amyloid-Tau-Neurodegeneration (ATN) plasma biomarkers and cognition have not been characterized in adults with type 1 diabetes (T1D).METHODS, Using data from participants in the Glycemic Variability and Fluctuations in Cognitive Status in Adults with T1D study (N=114), associations between phosphorylated tau (pTau)181, pTau217, β-amyloid 42/40 ratio, glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) and cognition measured by self-administered digital tests were investigated with adjustments for age, sex, education, comorbidities (e.g. kidney disease), and glycemic indices. RESULTS, Higher concentrations of pTau181 and GFAP were associated with slower responses on working memory tasks (pTau181: β=0.261 p=0.007; GFAP: β=0.175, p=0.036), and higher β-amyloid 42/40 ratio was associated with better vocabulary (β=0.260, p=0.009). Except for GFAP, these associations remained significant after adjustments. DISCUSION, Digital cognitive performance was associated with several ATN plasma biomarkers in T1D adults. Prospective studies are needed to understand the utility of these biomarkers in T1D.","journal":null,"year":2025,"id":574171,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9353,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":340324,"name":"Michal Schnaider Beeri","orcid":"0000-0002-4254-9742","position":1,"is_corresponding":false},{"id":759652,"name":"Zoë Hawks","orcid":"0000-0002-3796-0289","position":2,"is_corresponding":false},{"id":894877,"name":"Laneé Jung","orcid":"0000-0003-3555-5287","position":3,"is_corresponding":false},{"id":448796,"name":"Michael J. Cleveland","orcid":"0000-0002-7649-1323","position":4,"is_corresponding":false},{"id":710072,"name":"Nikki Delgado","orcid":"0000-0003-3999-6653","position":5,"is_corresponding":false},{"id":1057283,"name":"Jane Bulger","orcid":"0000-0002-3585-4896","position":6,"is_corresponding":false},{"id":677134,"name":"Elizabeth Grinspoon","orcid":"0000-0002-5608-8254","position":7,"is_corresponding":false},{"id":1057284,"name":"Kamille Janess","orcid":"0000-0001-5771-4133","position":8,"is_corresponding":false},{"id":320838,"name":"Martin J. Sliwinski","orcid":"0000-0002-9611-7558","position":9,"is_corresponding":false},{"id":231216,"name":"Ruth S. Weinstock","orcid":"0000-0001-5859-5666","position":10,"is_corresponding":false},{"id":301880,"name":"Jasmeer P. Chhatwal","orcid":"0000-0002-7792-1698","position":11,"is_corresponding":false},{"id":366456,"name":"Pia Kivisäkk","orcid":"0000-0001-9708-7509","position":12,"is_corresponding":false},{"id":258505,"name":"Laura Germine","orcid":"0000-0001-8690-8412","position":13,"is_corresponding":false},{"id":231679,"name":"Naomi Chaytor","orcid":"0000-0001-8821-289X","position":14,"is_corresponding":false},{"id":967426,"name":"Luciana Mascarenhas Fonseca","orcid":"0000-0002-2849-0545","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:57:40.686992Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}