{"doi":"10.31234/osf.io/qvn45","title":"Age-related reduction in anxiety and neural encoding of negative emotional memory","abstract":"Older people experience less anxiety. We examined how memory of negative emotional images varied with age and may reflect age-related differences in anxiety. Fifty-one adults, age 22-80 years, underwent imaging with a memory task where negative and neutral images were displayed pseudo-randomly. They were queried post-scan about the images inter-mixed with an equal number of images never displayed. Sensitivity (d’) and reporting bias (Z-score of false alarm rate; Z[FAR]) were quantified with signal detection theory. Age was negatively correlated with both Spielberg State Trait Anxiety Inventory (STAI) state score and d’ (negative – neutral) and positively with Z[FAR] (negative – neutral). However, STAI score and d’ or Z[FAR] (negative – neutral) were not significantly correlated. In whole-brain regression, STAI score was correlated with higher activity of the right middle/superior temporal gyri/temporal parietal junction (MTG/STG/TPJ) for “negative correct – incorrect” – “neutral correct – incorrect” trials. Further, the MTG/STG/TPJ activity (β) was also negatively correlated with age. Mediation analyses supported a complete mediation model of age less anxiety less MTG/STG/TPJ β. Together, the findings demonstrated age-related changes in negative emotional memory and how age-related reduction in anxiety is reflected in diminished temporoparietal cortical activities during encoding of negative emotional memory.","journal":"PsyArXiv (OSF Preprints)","year":2023,"id":400479,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9646,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":350394,"name":"Sheng Zhang","orcid":"0000-0001-5786-6516","position":1,"is_corresponding":false},{"id":320089,"name":"Yu Chen","orcid":"0000-0003-4946-4693","position":2,"is_corresponding":false},{"id":1093554,"name":"Jacqueline C. Dominguez","orcid":"0000-0003-2017-7797","position":3,"is_corresponding":false},{"id":523572,"name":"Herta H. Chao","orcid":"0000-0002-4827-6757","position":4,"is_corresponding":false},{"id":320093,"name":"Chiang‐Shan R. Li","orcid":"0000-0002-9393-1212","position":5,"is_corresponding":false},{"id":712607,"name":"Shefali Chaudhary","orcid":"0000-0003-4505-0506","position":0,"is_corresponding":true}],"reference_count":81,"raw_metadata":null,"created_at":"2026-07-19T01:20:04.010538Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}