{"doi":"10.31234/osf.io/gbc6s","title":"Personality Predictors of Dementia Diagnosis and Neuropathological Burden: An Individual Participant Data Meta-Analysis","abstract":"INTRODUCTION: The extent to which the Big Five personality traits and subjective well-being (SWB) are discriminatory predictors of clinical manifestation of dementia versus dementia-related neuropathology is unclear. METHODS: Using data from eight independent studies (Ntotal=44,531; Ndementia=1703; baseline Mage=49-81 years, 26-61% female; Mfollow-up range=3.53-21.00 years), Bayesian multilevel models tested whether personality traits and SWB differentially predicted neuropsychological and neuropathological characteristics of dementia.RESULTS: Synthesized and individual study results indicate that high neuroticism and negative affect and low conscientiousness, extraversion, and positive affect were associated with increased risk of long-term dementia diagnosis. There were no consistent associations with neuropathology.DISCUSSION: This multi-study project provides robust, conceptually replicated and extended evidence that psychosocial factors are strong predictors of dementia diagnosis but not consistently associated with neuropathology at autopsy.","journal":"PsyArXiv (OSF Preprints)","year":2023,"id":397494,"datarank":0.22448087907796238,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.05968903577774593,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.05968903577774593,"corpus_percentile":37.68855883035507,"corpus_rank":8056,"citation_count":2,"citer_count":2,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7476,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":477023,"name":"Tomiko Yoneda","orcid":"0000-0002-2906-1881","position":1,"is_corresponding":false},{"id":321317,"name":"Bryan D. James","orcid":"0000-0003-1932-151X","position":2,"is_corresponding":false},{"id":778,"name":"David A. Bennett","orcid":"0000-0003-3689-554X","position":3,"is_corresponding":false},{"id":226993,"name":"Jason Hassenstab","orcid":"0000-0002-7802-3371","position":4,"is_corresponding":false},{"id":251473,"name":"Mindy J. Katz","orcid":"0009-0004-7524-0292","position":5,"is_corresponding":false},{"id":234917,"name":"Richard B. Lipton","orcid":"0000-0003-2652-2897","position":6,"is_corresponding":false},{"id":27593,"name":"John C. Morris","orcid":"0000-0001-9820-5618","position":7,"is_corresponding":false},{"id":321321,"name":"Daniel K. Mroczek","orcid":"0000-0003-3748-5059","position":8,"is_corresponding":false},{"id":321316,"name":"Eileen K Graham","orcid":"0000-0003-3095-4625","position":9,"is_corresponding":false},{"id":767830,"name":"Emorie D Beck","orcid":"0000-0002-8152-3510","position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":null,"created_at":"2026-07-19T01:19:39.497368Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}