{"doi":"10.31234/osf.io/er3f4","title":"How can we use simultaneous microwire recordings from multiple areas to investigate inter-areal interactions?","abstract":"In the past few decades, significant progress has been made in understanding human cognition using intracranial electrophysiological recordings. Studies in this body of literature have focused on task-aligned tuning of spiking activity and features extracted from the local field potential (LFP). More recently, leveraging simultaneous and multi-site microelectrode recordings, it has become feasible to study interactions and information flow between multiple brain regions. Electrophysiological measures of coordination between brain areas are typically based on correlations of LFP-derived features, spike-timing, or some combination of the two. Any fluctuation in these measures has been interpreted to reflect changes in the unidirectional or bidirectional transmission of information between the two brain areas. Our goal in this chapter is to review: (1) the experimental evidence for inter-areal communication in microelectrode recordings, focusing on two test-cases of relevance, and (2) current methodological approaches and their possible (technical) limitations. The objective is to underscore the utility and importance of making such measurements in neural data, while cautioning against some common interpretational pitfalls and recommending validation approaches to avoid them.","journal":"PsyArXiv (OSF Preprints)","year":2022,"id":302848,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9423,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":994985,"name":"Jonathan Daume","orcid":"0000-0002-6516-7288","position":1,"is_corresponding":false},{"id":254814,"name":"Juri Minxha","orcid":"0000-0003-4942-3269","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-19T00:32:20.348385Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}