{"doi":"10.31234/osf.io/drwvg","title":"Associations Between a Genetic Liability Toward Behavioral Disinhibition and Externalizing Outcomes Spanning Toddlerhood Through Early Adulthood in Five Developmental Cohorts","abstract":"AbstractObjective: Understanding how genetic risk unfolds across development will be important for using genetics to inform prevention and early intervention. The current study leverages information from five large datasets to characterize behavioral manifestations of a genetic liability toward behavioral undercontrol from ages 6 months- 26 years. Method: We used polygenic scores (PGS) derived from a multivariate GWAS of Externalizing that identified genetic variants associated with behaviors related to behavioral undercontrol (EXTPGS) to estimate associations of genetic liability with relevant behavioral phenotypes within and across developmental periods, ranging from toddlerhood to early adulthood. We used data from five population- and family-based datasets spanning three countries. Objective: Understanding how genetic risk unfolds across development will be important for using genetics to inform prevention and early intervention. The current study leverages information from five large datasets to characterize behavioral manifestations of a genetic liability toward behavioral disinhibition from ages 6 months- 26 years. Method: We used polygenic scores (PGS) derived from a multivariate GWAS of Externalizing that identified genetic variants associated with behavioral disinhibition (EXTPGS) to estimate associations of genetic liability with relevant phenotypes within and across developmental periods, ranging from toddlerhood to early adulthood. We used data from five population- and family-based datasets spanning three countries. Results: The EXTPGS was significantly associated with a breadth of externalizing phenotypes from toddlerhood to early adulthood. Higher EXTPGS was consistently associated with measures of impulsivity from early adolescence to early adulthood. Individuals with higher EXTPGS were more likely to experience conduct problems and symptoms of oppositional defiant and attention-deficit/hyperactivity disorders. Further, the EXTPGS was associated with higher levels of substance use and problems beginning in early adolescence through early adulthood, including alcohol and other illicit drug use. There was minimal evidence for sex interactions. Conclusion: A genetic liability toward behavioral disinhibition is associated a wide array of behaviors and psychiatric/substance use outcomes from early childhood to emerging adulthood. These findings suggest that prevention and early intervention efforts should consider the breadth of adverse outcomes for which individuals carrying a genetic liability for behavioral disinhibition are at risk.","journal":"PsyArXiv (OSF Preprints)","year":2024,"id":487096,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7688,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":618521,"name":"Holly E. Poore","orcid":"0000-0003-0235-6070","position":1,"is_corresponding":false},{"id":434518,"name":"Sarah J. Brislin","orcid":"0000-0003-4303-8124","position":2,"is_corresponding":false},{"id":256430,"name":"Fazil Alıev","orcid":"0000-0001-8357-4699","position":3,"is_corresponding":false},{"id":230719,"name":"Stephanie Zellers","orcid":"0000-0001-8927-3483","position":4,"is_corresponding":false},{"id":320080,"name":"Peter B. Barr","orcid":"0000-0001-9321-657X","position":5,"is_corresponding":false},{"id":377313,"name":"Gretchen Saunders","orcid":"0000-0001-5972-9785","position":6,"is_corresponding":false},{"id":446084,"name":"Jessica E. Salvatore","orcid":"0000-0001-5504-5087","position":7,"is_corresponding":false},{"id":14729,"name":"Scott Vrieze","orcid":"0000-0003-3861-7930","position":8,"is_corresponding":false},{"id":257616,"name":"K. Paige Harden","orcid":"0000-0002-1557-6737","position":9,"is_corresponding":false},{"id":230002,"name":"Abraham A. Palmer","orcid":"0000-0003-3634-0747","position":10,"is_corresponding":false},{"id":1311043,"name":"Anu Raevuori","orcid":"0000-0001-7704-9441","position":11,"is_corresponding":false},{"id":264593,"name":"Antti Latvala","orcid":"0000-0001-5695-117X","position":12,"is_corresponding":false},{"id":230703,"name":"Danielle M. Dick","orcid":"0000-0002-1636-893X","position":13,"is_corresponding":false},{"id":1149115,"name":"Maia Choi","orcid":"0009-0007-9918-4901","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:08:06.013846Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}