{"doi":"10.31234/osf.io/cbygp","title":"Attenuated theta-band activity and cross-frequency coupling in schizophrenia during affective response inhibition","abstract":"Background: Individuals with Schizophrenia (SZ) display impaired cognitive control, including trouble inhibiting context-inappropriate responses; however, the underlying neural mechanisms remain understudied and unclear. The current study examined the role of theta-band (4-7 Hz) neural oscillatory activity and cross-frequency coupling with gamma (30-50 Hz) activity in an affective cognitive control paradigm in SZ in comparison with healthy controls (HC) and those with bipolar disorder (BD). Methods: Thirty-seven participants with SZ, 67 with BD, and 48 HC completed an affective Go/No-Go Task with emotional face stimuli during electroencephalography (EEG) recording. Time-frequency decomposition was used to extract theta-band power and intertrial phase consistency (ITPC) over midline fronto-central areas. The Kullback-Leibler Modulation Index was used to index theta-gamma phase-amplitude coupling (PAC) within the midline frontal area as well as between midline frontal theta and bilateral parietal gamma regions. Results: Participants with SZ displayed decreased midline frontal theta power, ITPC, and theta-gamma PAC compared to HC, with BD falling in between SZ and HC groups across all these measures. Theta power, ITPC, and theta-gamma PAC were correlated with behavioral performance in various ways, particularly in the SZ group. Conclusions: Collectively, these findings show abnormalities across the amplitude, phase consistency, and cross-frequency coordination aspects of theta-related activity when individuals with SZ engage in affective cognitive control. Implications for their contribution to functional impairment and directions for treatment are discussed.","journal":null,"year":2024,"id":490975,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9579,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":909114,"name":"Takakuni Suzuki","orcid":"0000-0003-4247-280X","position":1,"is_corresponding":false},{"id":996307,"name":"Margo W Menkes","orcid":"0000-0003-1912-8779","position":2,"is_corresponding":false},{"id":996308,"name":"Carolyn Andrews","orcid":"0000-0002-2105-9867","position":3,"is_corresponding":false},{"id":362434,"name":"Melvin G. McInnis","orcid":"0000-0002-0375-6247","position":4,"is_corresponding":false},{"id":463905,"name":"Patricia J. Deldin","orcid":"0000-0002-3584-3513","position":5,"is_corresponding":false},{"id":481688,"name":"Ivy F. Tso","orcid":"0000-0002-0984-1186","position":6,"is_corresponding":false},{"id":792134,"name":"Jacob D. Kraft","orcid":"0000-0001-9607-014X","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T02:08:41.211111Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}