{"doi":"10.31234/osf.io/5zfmn","title":"Children’s Pre-Scanning State Anxiety and Resting-State Functional Connectivity in Salience and Default Mode Networks: A Cross-Site Study","abstract":"Introduction: Even though resting-state functional connectivity (rs-FC) is conceptualized asmeasuring ‘intrinsic connectivity’, in-scanner experiences undoubtedly influence rs-FC. Themajority of work on anxiety and rs-FC does not consider the subjective state of the participantduring the magnetic resonance imaging (MRI) procedure. Heightened anxiety before an MRI(i.e., pre-scanning state anxiety), common in diverse samples, may be uniquely associated withindividual differences in brain activity. The current study assessed associations betweenpre-scanning state anxiety and rs-FC within and between the default mode network (DMN) andsalience network in a community sample of Latina girls (8-13 years) and a companion sample ofmixed treatment-seeking and healthy youth (8-18 years) of predominantly white background.Methods: A constrained network-based statistical approach calculated the average ofun-thresholded correlation coefficients from edge-level partial Spearman correlations to producenetwork-level measures. Statistics were compared against a null distribution based on averagedcorrelations from edge-level permutations to assess significance. Our hypothesis testing used athreshold of p < .05, which was then Bonferroni corrected (p < .00139).Results: We observed significant reductions in rs-FC within the DMN (r = -.32, p < .00139) as afunction of pre-scanning state anxiety in the community sample, but this did not replicate in ourcompanion sample.Discussion: Pre-scanning state anxiety is associated with rs-FC within the DMN, but onlyamong a community sample with elevated trait anxiety. This suggests that individual differencesin MRI scanning experiences may be associated with brain activity, but sample characteristicsshould be considered, and replication is needed.Keywords: pediatric anxiety, resting-state functional connectivity, default mode network,salience network, community samples","journal":null,"year":2025,"id":560429,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9549,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1213610,"name":"Dana E. Díaz","orcid":"0000-0002-4039-1128","position":1,"is_corresponding":false},{"id":79175,"name":"Brenda E. Benson","orcid":"0000-0002-3746-8657","position":2,"is_corresponding":false},{"id":72962,"name":"Daniel S. Pine","orcid":"0000-0002-4301-9516","position":3,"is_corresponding":false},{"id":697845,"name":"Peter Alexander Kirk","orcid":"0000-0003-0786-3039","position":4,"is_corresponding":false},{"id":79177,"name":"Kalina J. Michalska","orcid":"0000-0002-4830-5036","position":5,"is_corresponding":false},{"id":79173,"name":"Purnima Qamar","orcid":"0009-0000-1343-8325","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:55:42.883572Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}