{"doi":"10.31234/osf.io/3rm7f","title":"Polygenic Effects on Individual Rule Breaking, Peer Rule Breaking, and Alcohol Sips across Early Adolescence in the ABCD Study","abstract":"Genetic influences can underlie risky and delinquent behavior during adolescence as well as contribute to peer behavior via gene-environment correlations (rGE), which collectively increases risk for alcohol use. However, little research has examined this in early adolescence and even fewer studies exist in large diverse racial/ethnic populations. Data from the Adolescent Brain Cognitive Development (ABCD) study at age 11-12 (Mage=11.55; range 10-14) and age 12-13 (Mage=12.42; range 11-14) were used to examine a cross-time cross-lagged model in which polygenic scores for risky behavior were considered predictors of individual rule breaking, peer rule breaking, and alcohol sips. This was examined separately in European American (n=5113; 47% female), African American (n=1159; 50% female), and Hispanic (n=1624; 48% female) subgroups accounting for age, gender, site, income, and genetic principal components. In European Americans, polygenic scores were associated with individual and peer rule breaking at both ages. Individual and peer rule breaking were associated with one another within and across time. In African American and Hispanic subgroups, polygenic scores were associated with individual rule breaking at age 11-12. Individual and peer rule breaking were associated at age 11-12 in both subgroups and age 12-13 in the Hispanic subgroup. In all subgroups, peer rule breaking at 12-13 was associated with alcohol sips at 12-13. Results indicate that individual and peer rule breaking can influence one another within and across time with rGE likely implicated in European Americans. As a result, peer rule breaking can contribute to alcohol sips in early adolescence.","journal":"PsyArXiv (OSF Preprints)","year":2023,"id":402636,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9299,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":320082,"name":"Jinni Su","orcid":"0000-0002-9767-1489","position":1,"is_corresponding":false},{"id":256430,"name":"Fazil Alıev","orcid":"0000-0001-8357-4699","position":2,"is_corresponding":false},{"id":943328,"name":"Angel Trevino","orcid":"0000-0002-1511-1649","position":3,"is_corresponding":false},{"id":1180116,"name":"Jodi Kutzner","orcid":"0000-0002-0073-1298","position":4,"is_corresponding":false},{"id":1117394,"name":"Dong‐Chul Seo","orcid":"0000-0002-1972-6237","position":5,"is_corresponding":false},{"id":894348,"name":"Kit K. Elam","orcid":"0000-0003-0319-5897","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T01:20:27.903246Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}