{"doi":"10.31224/3249","title":"Framework for curvilinear catheter implantation in HDR prostate brachytherapy for dominant intraprostatic lesions (DIL) dose escalation – feasibility study","abstract":"BackgroundHigh-dose-rate (HDR) brachytherapy has been recognized as a popular treatment for patients with intermediate-and high-risk prostate cancer, despite its side-effects such as edema, incontinence, and impotence.Dose escalation to dominant intraprostatic lesions (DILs) results in improved cancer control.However, its application is limited due to the risk of excessive irradiation to organsat-risk (OARs) such as the urethra, bladder, rectum. MethodsThis work introduces curvilinear catheter implantation for dose escalation to the DIL, while reducing toxicity to OARs.Curvilinear catheters were first pre-planned for an anonymized patient using Oncentra treatment planning system (TPS) and hybrid inverse planning optimization (HIPO) algorithm.The curved needles were then analyzed using MATLAB to extract their radius of curvature.Tendon-driven active needles were then used to implant curvilinear catheters inside a patient-specific phantom tissue. ResultsProposed curvilinear catheter implantation resulted in significant improvement in dosimetric plans.Tendon-driven active needles were shown to be capable of realizing required pre-planned curvatures inside prostate.Accuracy of needle implantation was evaluated and reported. ConclusionsThis work demonstrates the feasibility of using tendon-driven active needles in curvilinear catheter implantation inside prostate to improve the outcomes of HDR-BT via dose escalation to the DILs and radiation dose reduction to the OARs.","journal":null,"year":2023,"id":411839,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9567,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1192840,"name":"Rex Imanaka","orcid":null,"position":1,"is_corresponding":false},{"id":1192438,"name":"Tarun K. Podder","orcid":"0000-0002-2925-1431","position":2,"is_corresponding":false},{"id":935774,"name":"Bardia Konh","orcid":"0000-0001-9700-8751","position":3,"is_corresponding":false},{"id":1111204,"name":"Blayton Padasdao","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T01:21:46.548301Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}