Patients diagnosed with basal-like breast cancer face a more aggressive disease course and more dismal prognosis than patients diagnosed with luminal A and luminal B breast cancer molecular subtypes (1-4). We mined published microarray data (5, 6) to understand in an unbiased fashion the most distinguishing transcriptional features of tumors from patients with basal or basal-like subtype breast cancer. We observed transcriptome-wide differential expression of MLX-interacting protein, MLXIP, when comparing tumors of patients with basal-like breast cancer with that of other PAM50 molecular subtypes. MLXIP mRNA was present at significantly higher quantities in the tumors of patients with basal-like breast cancer. Analysis of patient survival data revealed that MLXIP primary tumor expression was correlated with distant metastasis-free survival in HER2+ subtype breast cancer. Elevated MLXIP expression appears to distinguish basal-like human breast cancer from the other molecular subtypes.
","journal":null,"year":null,"id":594829,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":214855,"name":"Shahan Mamoor","orcid":"0000-0003-4150-0936","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Elevated MLXIP expression distinguishes basal-like human breast cancer.","abstract":"Patients diagnosed with basal-like breast cancer face a more aggressive disease course and more dismal prognosis than patients diagnosed with luminal A and luminal B breast cancer molecular subtypes (1-4). We mined published microarray data (5, 6) to understand in an unbiased fashion the most distinguishing transcriptional features of tumors from patients with basal or basal-like subtype breast cancer. We observed transcriptome-wide differential expression of MLX-interacting protein, MLXIP, when comparing tumors of patients with basal-like breast cancer with that of other PAM50 molecular subtypes. MLXIP mRNA was present at significantly higher quantities in the tumors of patients with basal-like breast cancer. Analysis of patient survival data revealed that MLXIP primary tumor expression was correlated with distant metastasis-free survival in HER2+ subtype breast cancer. Elevated MLXIP expression appears to distinguish basal-like human breast cancer from the other molecular subtypes.
","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23304386","pmcid":null,"openalex_id":"https://openalex.org/W4225261190","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"public-domain","oa_locations":[{"url":"https://osf.io/n26pe/download","host_type":""},{"url":"https://osf.io/n26pe/download","host_type":""},{"url":"https://doi.org/10.31219/osf.io/n26pe","host_type":""},{"url":"http://doi.org/10.31219/OSF.IO/N26PE","host_type":"repository"},{"url":"https://osf.io/n26pe","host_type":"repository"}],"fields_of_study":["Genomics and Chromatin Dynamics","Ubiquitin and proteasome pathways","Kruppel-like factors research"],"mesh_terms":[],"keywords":["Breast cancer","Basal (medicine)","Transcriptome","CA15-3","Oncology","Cancer","Microarray","Metastasis","Internal medicine","Tissue microarray","Medicine","Biology","Cancer research","Pathology","Gene expression","Gene","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T15:41:22.008021Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}