{"doi":"10.31219/osf.io/gxe7v","title":"Neutrophilia and NETopathy as Key Pathologic Drivers of Progressive Lung Impairment in Patients with COVID-19","abstract":"There is an urgent need for new therapeutic strategies to contain the spread of the novel coronavirus disease 2019 (COVID-19) and to curtail its most severe complications. Severely ill patients experience pathologic manifestations of acute respiratory distress syndrome (ARDS), and clinical reports demonstrate striking neutrophilia, elevated levels of multiple cytokines, and an exaggerated inflammatory response in fatal COVID-19. Mechanical respirator devices are the most widely applied therapy for ARDS in COVID-19. Despite mechanical ventilation, the current therapy is faced with poor survival and abnormal lung remodeling, and patients who recover often experience impaired cognition or physical disability. In this review, we argue the need to develop therapies aimed at inhibiting neutrophil recruitment, activation, degranulation, and neutrophil extracellular trap (NET) release as treatments for ARDS in COVID-19. Targeting host-mediated immunopathology holds promise to alleviate progressive pathologic complications of ARDS and reduce morbidities and mortalities in severely ill patients with COVID-19.","journal":"OSF Preprints (OSF Preprints)","year":2020,"id":121426,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9612,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":271470,"name":"Benjamin Tang","orcid":"0000-0002-1469-9540","position":1,"is_corresponding":false},{"id":271471,"name":"Martin Herrmann","orcid":"0000-0002-0258-2484","position":2,"is_corresponding":false},{"id":271472,"name":"Sylviane Muller","orcid":"0000-0002-0481-0620","position":3,"is_corresponding":false},{"id":271473,"name":"Vincent Chow","orcid":"0000-0003-2634-6213","position":4,"is_corresponding":false},{"id":271474,"name":"Marko Radic","orcid":"0000-0002-8004-282X","position":5,"is_corresponding":false},{"id":271469,"name":"Teluguakula Narasaraju","orcid":"0000-0001-5307-1302","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-18T23:14:42.734024Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}