{"doi":"10.31219/osf.io/f9vqc","title":"The need for validation in layer-specific fMRI","abstract":"There has been much recent interest in using sub-millimeter fMRI to study neural activity at the laminar scale. While the number of neuroscientific papers using layer-specific fMRI has grown rapidly, we urge a re-assessment of whether currently available fMRI techniques can accurately and reliably measure laminar patterns of neural activity. In this short review, we highlight three main challenges that impede accurate inferences, and contend that the field of layer-specific fMRI should place greater emphasis on validation. In particular, we propose that acquisition and analysis approaches should be thoroughly evaluated with simulations and ground-truth data. These steps are necessary for layer-specific fMRI to become a valid tool in systems neuroscience.","journal":"OSF Preprints (OSF Preprints)","year":2022,"id":298871,"datarank":0.3071251614237968,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.03836124103958853,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.03836124103958853,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":5,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9526,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":319867,"name":"Kendrick Kay","orcid":"0000-0001-6604-9155","position":1,"is_corresponding":false},{"id":278079,"name":"Elisha P. Merriam","orcid":"0000-0003-2787-566X","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:31:40.528568Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}