{"doi":"10.31219/osf.io/3ascm","title":"The Voice Inside Your Head: Intracranial Examination of High Frequency Activity and Phase Amplitude Coupling During Natural Language","abstract":"Many studies have investigated brain network dynamics involved in language, but most have done so from the scalp and focused on discrete components of language. Functional mapping using stereoelectroencephalography (SEEG) offers a unique opportunity to directly examine eloquent cortex supporting language. Picture naming is the most common task used during SEEG to map language but may not adequately capture neural network dynamics involved in “natural” language used in everyday conversation. In this exploratory case report, we used SEEG to examine high-frequency activity (HFA) and phase-amplitude coupling (PAC) in a 20-year-old patient with drug-resistant epilepsy, comparing spontaneous conversation with a picture naming task. Examination of HFA and PAC during the conversation showed a broad neural activation network that included canonical language regions and regions believed to be important for reasoning, monitoring behavior, and decision-making (i.e., bilateral frontal, temporal, and parietal activation). In comparison, HFA and PAC during picture naming were limited to the left temporal region and right superior frontal gyrus. Findings suggest natural language is supported by a broader network than is captured using an elemental, single-domain language task. While additional research is needed to substantiate these results, our findings suggest it may be possible to explore more complex (network-based) features of language processing using SEEG.","journal":"OSF Preprints (OSF Preprints)","year":2024,"id":493885,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9497,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":997608,"name":"Andrew Ehrenberg","orcid":null,"position":1,"is_corresponding":false},{"id":1105059,"name":"Rachael M. 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