{"doi":"10.3109/13550284.2010.504249","title":"Longitudinal psychomotor speed performance in human immunodeficiency virus–seropositive individuals: impact of age and serostatus","abstract":null,"journal":"Journal of Neurovirology","year":2010,"id":596370,"datarank":0.5897738449086489,"base_score":3.9318256327243257,"endowment":3.9318256327243257,"self_citation_contribution":0.5897738449086489,"citation_network_contribution":0.0,"self_endowment_contribution":0.5897738449086489,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":50,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1527385,"name":"Richard L Skolasky","orcid":null,"position":1,"is_corresponding":false},{"id":329166,"name":"Christopher Cox","orcid":"0000-0003-1547-0518","position":2,"is_corresponding":false},{"id":1527389,"name":"Ola Selnes","orcid":null,"position":3,"is_corresponding":false},{"id":1527391,"name":"James T Becker","orcid":null,"position":4,"is_corresponding":false},{"id":567156,"name":"Bruce Cohen","orcid":"0000-0003-2913-6238","position":5,"is_corresponding":false},{"id":1225929,"name":"Eileen Martin","orcid":"0000-0002-3420-4971","position":6,"is_corresponding":false},{"id":1527396,"name":"Eric N Miller","orcid":null,"position":7,"is_corresponding":false},{"id":369119,"name":"Ned Sacktor","orcid":"0000-0001-5349-8058","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Longitudinal psychomotor speed performance in human immunodeficiency virus–seropositive individuals: impact of age and serostatus","abstract":"Older human immunodeficiency virus-seropositive (HIV+) individuals (greater than age 50 years) are twice as likely to develop HIV dementia compared to younger HIV+ individuals. The objective of this study was to examine the impact of both age and serostatus on longitudinal changes in psychomotor speed/executive functioning performance among HIV+ and HIV− individuals. Four hundred and seventy-seven HIV+ and 799 HIV− individuals from the Multicenter AIDS Cohort Study (MACS) were subdivided into three age groups: (1) <40 years, (2) 40-50 years, and (3) >50 years. Psychomotor speed/executive functioning test performance was measured by the Symbol Digit Modalities Test (SDMT) and the Trail Making (TM) Test Parts A and B. Changes in performance were compared among the three age groups for both HIV+ and HIV− individuals. Among HIV+ individuals, on the TM Test Part B the younger group demonstrated improvement in performance over time (P = .007). The older and middle age groups demonstrated decline in performance over time (P = .041 and .030). The older group had a significantly different trajectory relative to the younger group (P = .046). Among the HIV− individuals, there was no effect of age on longitudinal performance. In conclusion, older HIV+ individuals show greater decline over time than younger HIV+ individuals on the TM Test Part B. Our results suggest that both HIV serostatus and age together may impact longitudinal performance on this test. Mild neurocognitive changes over time among older HIV+ individuals are likely to reflect age associated pathophysiological mechanisms including cerebrovascular risk factors.","is_dataset_classified":null,"base_score":3.9318256327243257,"endowment":3.9318256327243257,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20726699","pmcid":"PMC3068912","openalex_id":"https://openalex.org/W2147218987","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"P01 NS026643","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"M01 RR000052","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH080636","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U01 AI035042","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U01 AI035043","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U01-AI-35040","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"MH-71150","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"RR-00722","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U01-AI-35039","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"5-M01-RR-00052","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"NS-26643","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U01 AI035039","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH071150","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U01 AI035040","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U01 AI035041","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U01-AI-35043","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"M01 RR000722","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U01-AI-35041","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U01-AI-35042","title":null},{"funder_name":"National Institutes of Health","grant_id":"5U01AI035043-18","title":"Center/Coordination, Analysis and Management/MACS"},{"funder_name":"National Institutes of Health","grant_id":"3U01AI035040-01S1","title":"NATURAL HISTORY OF AIDS IN HOMOSEXUAL MEN"},{"funder_name":"National Institutes of Health","grant_id":"5R01MH071150-04","title":"Oxidative Stress Markers and HIV Dementia"},{"funder_name":"National Institutes of Health","grant_id":"5U01AI035041-26","title":"University of Pittsburgh Multicenter AIDS Cohort Study (MACS)"},{"funder_name":"National Institutes of Health","grant_id":"5U01AI035042-21","title":"Multicenter AIDS Cohort Study - Part B (Baltimore Center)"},{"funder_name":"National Institutes of Health","grant_id":"5U01AI035039-15","title":"MULTICENTER AIDS COHORT STUDY"},{"funder_name":"National Institutes of Health","grant_id":"5P01NS026643-12","title":"CORE--NEUROPATHOLOGY"},{"funder_name":"National Institutes of Health","grant_id":"3M01RR000052-31S3","title":"GCRC-RENOVATION"}],"total_grants":27,"fwci":1.3235,"citation_percentile":0.77946373,"influential_citations":0,"citation_trend":[{"year":2012,"count":6},{"year":2013,"count":1},{"year":2014,"count":5},{"year":2015,"count":5},{"year":2016,"count":5},{"year":2017,"count":3},{"year":2018,"count":8},{"year":2019,"count":4},{"year":2020,"count":1},{"year":2021,"count":2},{"year":2022,"count":2},{"year":2024,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://doi.org/10.3109/13550284.2010.504249","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20726699","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3068912","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc3068912?pdf=render","host_type":""},{"url":"https://dx.doi.org/10.3109/13550284.2010.504249","host_type":""}],"fields_of_study":["HIV Research and Treatment","HIV-related health complications and treatments","HIV/AIDS Research and Interventions","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["Adult","Age Factors","HIV Seropositivity","Humans","Middle Aged","Psychomotor Disorders","Risk Factors","Task Performance and Analysis","United States","Cohort Studies","Multicenter Studies as Topic","AIDS Dementia Complex","HIV Seronegativity","Anti-HIV Agents","Antiretroviral Therapy, Highly Active"],"keywords":["Serostatus","Multicenter AIDS Cohort Study","Psychomotor learning","Neurocognitive","Trail Making Test","Medicine","Longitudinal study","Dementia","Cohort","Human immunodeficiency virus (HIV)","Psychology","Immunology","Viral load","Viral disease","Internal medicine","Neuropsychology","Sida","Cognition","Psychiatry","Disease","Pathology","Adult","AIDS Dementia Complex","Anti-HIV Agents","Age Factors","Middle Aged","United States","Cohort Studies","Risk Factors","Antiretroviral Therapy, Highly Active","HIV Seronegativity","HIV Seropositivity","Task Performance and Analysis","Humans","Multicenter Studies as Topic","Psychomotor Disorders"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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