{"doi":"10.3109/10428199409056287","title":"Endogenous Production and Peripheral Blood Levels of Granulocyte-Macrophage (GM\n                    <sub>-</sub>\n                    ) and Granulocyte (G\n                    <sub>-</sub>\n                    ) Colony-Stimulating Factors","abstract":null,"journal":"Leukemia &amp; Lymphoma","year":1994,"id":682289,"datarank":0.6064576901751826,"base_score":4.04305126783455,"endowment":4.04305126783455,"self_citation_contribution":0.6064576901751826,"citation_network_contribution":0.0,"self_endowment_contribution":0.6064576901751826,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":56,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1782489,"name":"Bengt Sallerfors","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Endogenous Production and Peripheral Blood Levels of Granulocyte-Macrophage (GM\n                    <sub>-</sub>\n                    ) and Granulocyte (G\n                    <sub>-</sub>\n                    ) Colony-Stimulating Factors","abstract":"Granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) are two important granulopoietic growth factors. This review will focus on the endogenous production of human GM-CSF and human G-CSF and its possible reflection in circulating levels in peripheral blood. When adequately stimulated a variety of cell-types such as monocytes/macrophages. T-lymphocytes, endothelial cells and fibroblasts can produce CSFs in vitro. G-CSF can increase to detectable levels in peripheral blood when there is a demand for granulocyte production such as acute neutropenic in conjunction with hematological disorders, chronic neutropenic conditions and acute infectious diseases in patients with or without underlying hematological disorders. G-CSF in peripheral blood is detected more often and in higher concentrations than GM-CSF. An independent regulation of GM-CSF and G-CSF secretion, quantitative differences in production and/or differences in elimination or distribution might be of importance.","is_dataset_classified":null,"base_score":4.04305126783455,"endowment":4.04305126783455,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"7519508","pmcid":null,"openalex_id":"https://openalex.org/W1985193006","authors":[],"funders":[],"total_grants":0,"fwci":1.0092,"citation_percentile":0.75711256,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":1},{"year":2014,"count":1},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2019,"count":5},{"year":2020,"count":3},{"year":2024,"count":2},{"year":2025,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.3109/10428199409056287","host_type":"publisher"},{"url":"https://doi.org/10.3109/10428199409056287","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/7519508","host_type":"repository"}],"fields_of_study":["Immune Response and Inflammation","Immune cells in cancer","Neutropenia and Cancer Infections"],"mesh_terms":["Animals","Antineoplastic Agents","Bone Marrow","Endothelium","Fibroblasts","Gene Expression Regulation","Hematopoiesis","Humans","Infections","Inflammation","Leukemia","Neutropenia","Phagocytes","Bone Marrow Transplantation","Lymphocyte Subsets","Granulocyte-Macrophage Colony-Stimulating Factor","Granulocyte Colony-Stimulating Factor"],"keywords":["Granulocyte","Granulocyte macrophage colony-stimulating factor","Peripheral blood","Immunology","Granulocyte colony-stimulating factor","Granulocyte macrophage colony-stimulating factor receptor","Endogeny","Medicine","Macrophage","Biology","Cytokine","Internal medicine","Biochemistry","In vitro","Macrophage colony-stimulating factor","Chemotherapy"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T19:59:17.608828Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}